Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse A review 英文参考文献.docVIP

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Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse A review 英文参考文献.doc

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Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse A review 英文参考文献

Genet. Sel. Evol. 33(2001) 105–132 ?INRA, EDP Sciences, 2001 105 Review QuantitativeTraitLoci(QTLs)mapping forgrowthtraitsinthemouse: Areview PabloM.CORVA,JuanF.MEDRANO ? DepartmentofAnimalScience,UniversityofCalifornia,OneShieldsAve.,Davis, CA95616–8521,USA (Received4July2000;accepted28November2000) Abstract– The attainment of a speci?c mature body size is one of the most fundamental differencesamongspeciesofmammals. Moreover,bodysizeseemstobethecentralfactor underlyingdifferencesintraitssuchasgrowthrate,energymetabolismandbodycomposition. Animportantproportionofthisvariabilityisofgeneticorigin.Thegoalofthegeneticanalysis ofanimalgrowthistounderstandits“geneticarchitecture”,thatisthenumberandpositionof lociaffectingthetrait,themagnitudeoftheireffects,allelefrequenciesandtypesofgeneaction. Inthisreview,thedifferentstrategiesdevelopedtoidentifyandcharacterizegenesinvolvedin theregulationofgrowthinthemousearedescribed,withemphasisonthemethodsdeveloped tomaplocicontributingtotheregulationofquantitativetraits(QTLs). genetics/growth/mouse/mapping/QTLs 1.INTRODUCTION Thematurebodysizeofananimalisdeterminedbythenumberandsize of itscells, andtheamount of extracellularmatrixand?uid[23], withcell numbermakingamajorcontribution[2].Acrucialfeatureofthedevelopment ofmammalsisthatatagivenpoint,ananimalstopsgrowing,reachingatthat point a maximum cell mass. It is accepted that the genetic makeup of the individualplaysapredominantroleinthedeterminationofthatendpoint,but theunderlyinggeneticmechanismsarenotwellunderstood[23]. Therefore, oneoftheprimaryobjectivesofthegeneticanalysisofanimalgrowthisto understandits“geneticarchitecture”,thatisthenumberandpositionofloci affectingthetrait,themagnitudeoftheireffects,allelefrequenciesandtypes ofgeneaction[12,128]. Themousehasbeenextensivelyusedasamodeltostudythegeneticsof growthinmammals. InformationcompiledintheMouseGenomeDatabase (MGD)[87]givesanideaofthecomplexityofthegeneticregulationofgrowth ?Correspondenceandreprints E