Quantitative genomics of locomotor behavior in Drosophila melanogaster 英文参考文献.docVIP

Open Access Re rch 2007JordanetVoal.lumesea8, Issue 8, Article R172 Quantitative genomics of locomotor behavior in Drosophila melanogaster Katherine W Jordan*, Mary Anna Carbone*, Akihiko Yamamoto*, Theodore J Morgan? and Trudy FC Mackay* Addresses: *Department of Genetics and WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695-7614, USA. ?Division of Biology, Kansas State University, Ackert Hall, Manhattan, KS 66506, USA. Correspondence: Trudy FC Mackay. Email: trudy_mackay@ Published: 21 August 2007 Received: 18 December 2006 Revised: 26 March 2007 Accepted: 21 August 2007 Genome Biology 2007, 8:R172 (doi:10.1186/gb-2007-8-8-r172) The electronic version of this article is the complete one and can be found online at /2007/8/8/R172 ? 2007 Jordan et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License /licenses/by/2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. GenomicspoppuTlhateioloncof,osmflyhoowtlocomotionirngbehaviort t maofnyDrosophilapleiotropicmelanogastergenes show cowasrrelaquantifiedted transcrinipatilargeonal rpopulationes onses toofminbredultiplelinesbehaderivedviors./fromp a single natural Abstract Background: Locomotion is an integral component of most animal behaviors, and many human health problems are associated with locomotor deficits. Locomotor behavior is a complex trait, with population variation attributable to many interacting loci with small effects that are sensitive to environmental conditions. However, the genetic basis of this complex behavior is largely uncharacterized. Results: We quantified locomotor behavior of Drosophila melanogaster in a large population of inbred lines derived from a single natural population, and derived replicated selection lines with different le