Quantitative genomics of starvation stress resistance in Drosophila 英文参考文献.docVIP

Open Access Re rch 2005HarbisonetVoal.lumesea6, Issue 4, Article R36 Quantitative genomics of starvation stress resistance in Drosophila Susan T Harbison*?§, Sherman Chang?, Kim P Kamdar? and Trudy FC Mackay*? Addresses: *Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA. ?WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA. ?The Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA. §Current address: Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA. Correspondence: Trudy FC Mackay. E-mail: trudy_mackay@ Published: 24 March 2005 Received: 24 August 2004 Revised: 22 December 2004 Accepted: 23 February 2005 Genome Biology 2005, 6:R36 (doi:10.1186/gb-2005-6-4-r36) The electronic version of this article is the complete one and can be found online at /2005/6/4/R36 ? 2005 Harbison et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. QuantitativesbcipnriapTnthitoeineabflrfiercedagenomicssclpiynoenfssetdretaorniofsvtceardstarvationripvfrtaiotoimonnatlhspetrrmstresseos,fiswliiannsgresistancemsfhoaorlewisdneantnotdibfinfyeeimndDrosophilagiafflnetworkserseonfttbheetwOoferepleiotropicgnotnh-eRseaxnedsgenes2abndittoregulatingiDnrvooslvoephapicomplexlparo/xitimsatraitsttrealyin2s5was, %asowassessed.fethlleagsefnoouThemr ree.ctran-om-/p Abstract Background: A major challenge of modern biology is to understand the networks of interacting genes regulating complex traits, and the subset of these genes that affect naturally occurring quantitative genetic variation. Previously, we used P-element mutagenesis and quantitative trait locus (QTL) mapping in Drosophila to identify