Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis 英文参考文献.docVIP

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Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis 英文参考文献.doc

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Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis 英文参考文献

Rab11A-ControlledAssemblyoftheInnerMembrane ComplexIsRequiredforCompletionofApicomplexan Cytokinesis CarolinaAgop-Nersesian1.,BerninaNaissant2.,FathiaBenRached2,ManuelRauch1 ,Angelika Kretzschmar1,SabineThiberge3,RobertMenard3,DavidJ.P.Ferguson4,MarkusMeissner1* ,Gordon Langsley2* 1Hygieneinstitut,DepartmentofParasitology,UniversityHospitalHeidelberg,Heidelberg,Germany,2LaboratoiredeBiologieCellulaireComparativedesApicomplexes, Department ofInfectiousDiseases, Institut Cochin,InsermU567,CNRS UMR8104,Faculte′ deMe′decine ParisV–Ho?pitalCochin, Paris, France, 3Unite′ deBiologieet Ge′ne′tiqueduPaludisme,InstitutPasteur,Paris,France,4NuffieldDepartmentofPathology,UniversityofOxford,JohnRadcliffeHospital,Oxford,UnitedKingdom Abstract Thefinalstepduringcelldivisionistheseparationofdaughtercells,aprocessthatrequiresthecoordinateddeliveryand assemblyofnewmembranetothecleavagefurrow.Whilemosteukaryoticcellsreplicatebybinaryfission,replicationof apicomplexanparasitesinvolvestheassemblyofdaughters(merozoites/tachyzoites)withinthemothercell,usingtheso- calledInnerMembraneComplex(IMC)asascaffold.AfterdenovosynthesisoftheIMCandbiogenesisorsegregationof neworganelles,daughtersbudoutofthemothercelltoinvadenewhostcells.Here,wedemonstratethatthefinalstepin parasite cell division involves delivery of new plasma membrane to the daughter cells, in a process requiring functional Rab11A.Importantly,Rab11AcanbefoundinassociationwithMyosin-Tail-Interacting-Protein(MTIP),alsoknownasMyosin LightChain1(MLC1),amemberofa4-proteinmotorcomplexcalledtheglideosomethatisknowntobecrucialforparasite invasionofhostcells.AblationofRab11AfunctionresultsindaughterparasiteshavinganincompletelyformedIMCthat leadstoablockatalatestageofcelldivision.AsimilardefectisobserveduponinducibleexpressionofamyosinAtail-only mutant.WeproposeamodelwhereRab11A-mediatedvesiculartrafficdrivenbyanMTIP-MyosinmotorisnecessaryforIMC maturationandtodelivernewplasmamembranetodaughtercellsinordertocompletecelldivision. Citat