Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells 英文参考文献.docVIP
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Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells 英文参考文献
QuercetinSuppressesDrug-ResistantSpheresviathe
p38MAPK–Hsp27ApoptoticPathwayinOralCancer
Cells
Su-FengChen1,ShinNieh2*.,Shu-WenJao3,Chia-LinLiu4,Chien-HuaWu4,Yun-ChingChang4 ,Chin-
YuhYang5,Yaoh-ShiangLin
6,7 .
*
1DepartmentofDentalHygiene,ChinaMedicalUniversity,Taichung,Taiwan,2DepartmentofPathology,Tri-ServiceGeneralHospitalNationalDefenseMedicalCenter,
Taipei,Taiwan,3DivisionofColonandRectalSurgery,Tri-ServiceGeneralHospitalNationalDefenseMedicalCenter,Taipei,Taiwan,4GraduateInstituteofLifeSciences,
National Defense Medical Center, Taipei, Taiwan, 5Department of Dentistry, Shuang Ho Hospital Taipei Medical University, Taipei, Taiwan, 6Department of
Otolaryngology-HeadandNeckSurgery,Tri-ServiceGeneralHospitalNationalDefenseMedicalCenter,Taipei,Taiwan,7DepartmentofOtolaryngology-HeadandNeck
Surgery,ChungShanMedicalUniversity,Taichung,Taiwan
Abstract
Background: Treatment failure in oral squamous cell carcinoma (OSCC) leading to local recurrence(s) and metastases is
mainlyduetodrugresistance.Cancerstemcells(CSCs)arethoughtberesponsibleforthedevelopmentofdrugresistance.
However,thecorrelationsbetweenCSCs,drugresistance,andnewstrategyagainstdrugresistanceinOSCCremainelusive.
Methods: A drug-resistant sphere (DRSP) model was generated by using a nonadhesive culture system to induce drug-
resistant cellsfromSCC25oralcancer cells.Acomparative analysiswasperformed betweentheparentcontrolcells and
DRSPswitharelatedtreatmentstrategyfocusingontheexpressionofepithelial–mesenchymaltransition(EMT)-associated
markers,drug-resistance-relatedgenes, andCSC properties invitro,aswellastumorigenicity andtheregimenfortumor
regressioninvivo.
Results: Our data show the presence of a phenomenon of EMT with gradual cellular transition from an epithelioid to
mesenchymal-like spheroid morphology during induction of drug resistance. The characterization of DRSPs revealed the
upregulationofthedrug-resistance-relatedgenesABCG2andMDR-1andofCSC-representativemarkers,suggestingthat
DRS
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