Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers an evaluation from 1 to 4 years after diagnosis 英文参考文献.docVIP

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Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers an evaluation from 1 to 4 years after diagnosis 英文参考文献.doc

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Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers an evaluation from 1 to 4 years after diagnosis 英文参考文献

Available online /content/8/1/R31 Research article Open Access Vol 8 No 1 Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis SMM Verstappen1, AR Poole2, M Ionescu2, LE King3, M Abrahamowicz4, DM Hofman5, JWJ Bijlsma1, FPJG Lafeber1 and the Utrecht Rheumatoid Arthritis Cohort Study group (SRU) 1Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands 2Joint Disease Laboratory, Shriners Hospital for Children, Departments of Surgery and Medicine, McGill University, Montreal, Canada 3IBEX Pharmaceuticals, Montreal, Canada 4Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada 5Department of Rheumatology, Hilversum Hospital, Hilversum, The Netherlands Corresponding author: SMM Verstappen, s.verstappen@azu.nl Received: 11 Jul 2005 Revisions requested: 22 Aug 2005 Revisions received: 28 Nov 2005 Accepted: 9 Dec 2005 Published: 10 Jan 2006 Arthritis Research Therapy 2006, 8:R31 (doi:10.1186/ar1882) This article is online at: /content/8/1/R31 ? 2006 Verstappen et al.; licensee BioMed Central Ltd. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). per year) were compared. In addition, we evaluated the long- term and short-term predictive value of each biomarker for progression of radiographic damage. Results Patients with rapid radiographic progression had higher C2