RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models comparison with anti-TNFα or anti-IL-1 therapies 英文参考文献.docVIP

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RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models comparison with anti-TNFα or anti-IL-1 therapies 英文参考文献.doc

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RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models comparison with anti-TNFα or anti-IL-1 therapies 英文参考文献

Available online /content/11/6/R187 Research article Open Access Vol 11 No 6 RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies Marina Stolina1, Georg Schett2,3, Denise Dwyer1, Steven Vonderfecht4, Scot Middleton2, Diane Duryea4, Efrain Pacheco4, Gwyneth Van4, Brad Bolon4,5, Ulrich Feige2,6, Debra Zack2 and Paul Kostenuik1 1Department of Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA 2Department of Inflammation, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA 3Current address: Department of Internal Medicine 3, University of Erlangen-Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany 4Department of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA 5Current address: GEMpath, 2867 Humboldt Circle, Longmont, CO 80503, USA 6Current address: EUROCBI GmbH, Bodenacherstrasse 87, 8121 Benglen-Zurich, Switzerland Corresponding author: Marina Stolina, mstolina@ Received: 31 Mar 2009 Revisions requested: 22 May 2009 Revisions received: 17 Nov 2009 Accepted: 11 Dec 2009 Published: 11 Dec 2009 Arthritis Research Therapy 2009, 11:R187 (doi:10.1186/ar2879) This article is online at: /content/11/6/R187 ? 2009 Stolina et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Rat adjuvant-induced arthritis (AIA) and collagen- induced arthritis (CIA) feature bone loss and systemic increases in TNFα, IL-1β, and receptor activator of NF-κB ligand (RANKL). paw swelling in both models, and reduced ankle BMD loss in AIA rats. Anti-IL-1 decreased paw swelling in CIA rats, and reduced ankle BMD loss in b