Recent Rapid Rise of a Permethrin Knock Down Resistance Allele in Aedes aegypti in México 英文参考文献.docVIP
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Recent Rapid Rise of a Permethrin Knock Down Resistance Allele in Aedes aegypti in México 英文参考文献
RecentRapidRiseofaPermethrinKnockDown
ResistanceAlleleinAedesaegyptiinMe′xico
GustavoPonceGarc?′a1,AdrianaE.Flores1,IldefonsoFerna′ndez-Salas1,KarlaSaavedra-Rodr?′guez2,
GuadalupeReyes-Solis2,SaulLozano-Fuentes2,J.GuillermoBond3,MauricioCasas-Mart?′nez3,JanineM.
Ramsey3,Julia′nGarc?′a-Rejo′n4,MarcoDom?′nguez-Galera5,HilaryRanson6,JanetHemingway6 ,Lars
Eisen2,WilliamC.Black,IV2*
1Laboratorio de Entomolog?′a Me′dica, Facultad de Ciencias Biolo′gicas, Universidad Auto′noma de Nuevo Leo′n, San Nicola′s de los Garza, Nuevo Leo′n, Me′xico,
2Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America, 3Centro Regional de
Investigacio′n en Salud Pu′blica, Instituto Nacional de Salud Pu′blica, Tapachula, Chiapas, Me′xico, 4Universidad Auto′noma de Yucata′n, Laboratorio de Arbovirolog?′a,
CentrodeInvestigacionesRegionalesDr.HideyoNoguchi,UniversidadAuto′nomadeYucata′n, Me′rida, Yucata′n, Me′xico,5ServiciosEstatalesdeSaluddeQuintanaRoo,
ServiciosEstatalesdeSaluddeQuintanaRoo,Chetumal,QuintanaRoo,Me′xico,6VectorGroup,LiverpoolSchoolofTropicalMedicine,Liverpool,UnitedKingdom
Abstract
Background: Aedes aegypti, the ‘yellow fever mosquito’, is the primary vector to humans of dengue and yellow fever
flaviviruses(DENV,YFV),andisaknownvectorofthechikungunyaalphavirus(CV).Becausevaccinesarenotyetavailable
for DENV or CV or are inadequately distributed in developing countries (YFV), management of Ae. aegypti remains the
primaryoptiontopreventandcontroloutbreaksofthediseasescausedbythesearboviruses.Permethrinisoneofthemost
widelyusedactiveingredientsininsecticidesforsuppressionofadultAe.aegypti.In2007,wedocumentedareplacement
mutationincodon1,016ofthevoltage-gatedsodiumchannelgene(para)ofAe.aegyptithatencodesanisoleucinerather
thanavalineandconfersresistancetopermethrin.Ile1,016segregatesasarecessivealleleconferringknockdownresistance
tohomozygousmosquitoesat5–10mgofpermethrininbottlebioassays.
MethodsandFindin
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