Recognition of Morphometric Vertebral Fractures by Artificial Neural Networks Analysis from GISMO Lombardia Database 英文参考文献.docVIP

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Recognition of Morphometric Vertebral Fractures by Artificial Neural Networks Analysis from GISMO Lombardia Database 英文参考文献.doc

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Recognition of Morphometric Vertebral Fractures by Artificial Neural Networks Analysis from GISMO Lombardia Database 英文参考文献

RecognitionofMorphometricVertebralFracturesby ArtificialNeuralNetworks:AnalysisfromGISMO LombardiaDatabase CristinaEller-Vainicher1*,IacopoChiodini1,IvanaSanti2,MarcoMassarotti3,LucaPietrogrande4 ,Elisa Cairoli1,PaoloBeck-Peccoz1,MatteoLonghi5,ValterGalmarini6,GiorgioGandolini7 ,Maurizio Bevilacqua8,EnzoGrossi9,10 1Endocrinology and Diabetology Unit, Medical Sciences Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca` Granda Ospedale Maggiore Policlinico,Milan,Italy,2IstitutoGeriatricoAziendadiServiziallaPersonaIstitutiMilanesiMartinitteStellineePioAlbergoTrivulzio,Milan,Italy,3IstitutodiRicoveroe CuraaCarattereScientificoHumanitas,Rozzano,Milan,Italy,4OrthopedicClinic,DipartimentodiMedicina,ChirurgiaeOdontoiatriaSanPaolo,UniversityofMilan,Milan, Italy, 5Unit of Reumathology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Ortopedico Galeazzi, Milan, Italy, 6Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan,Italy, 7Istituto diRicoveroeCura aCarattereScientifico DonGnocchi, Milan, Italy, 8EndocrinologyandDiabetesUnit,LuigiSacco Hospital(Vialba), UniversityofMilan,Milan,Italy,9BraccoMedicalDepartment,SanDonatoMilanese,Milan,Italy,10SemeionResearchCentre,Rome,Italy Abstract Background: It is known that bone mineral density (BMD) predicts the fracture’s risk only partially and the severity and number of vertebral fractures are predictive of subsequent osteoporotic fractures (OF). Spinal deformity index (SDI) integrates the severity and number of morphometric vertebral fractures. Nowadays, there is interest in developing algorithms that use traditional statistics for predicting OF. Some studies suggest their poor sensitivity. Artificial Neural Networks(ANNs)couldrepresentanalternative.Sofar,nostudyinvestigatedANNsabilityinpredictingOFandSDI.Theaim ofthepresentstudyistocompareANNsandLogisticRegression(LR)inrecognising,onthebasisofosteoporoticrisk-factors andotherclinicalinformation,patientswithSDI$1andSDI$5fromthosewithSDI