Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain 英文参考文献.docVIP

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Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain 英文参考文献.doc

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Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain 英文参考文献

RelationshipsbetweenGeneExpressionandBrainWiring intheAdultRodentBrain LeonFrench1,2,PaulPavlidis2,3 * 1Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada, 2Centre for High-Throughput Biology, University of British Columbia,Vancouver,BritishColumbia,Canada,3DepartmentofPsychiatry,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada Abstract Westudiedtheglobalrelationshipbetweengeneexpressionandneuroanatomicalconnectivityintheadultrodentbrain. We utilized a large data set of the rat brain ‘‘connectome’’ from the Brain Architecture Management System (942 brain regionsandover5000connections)andusedstatisticalapproachestorelatethedatatothegeneexpressionsignaturesof 17,530genesin142anatomicalregionsfromtheAllenBrainAtlas.Ouranalysisshowsthatadultgeneexpressionsignatures haveastatisticallysignificantrelationshiptoconnectivity.Inparticular,brainregionsthathavesimilarexpressionprofiles tendtohavesimilarconnectivityprofiles,andthiseffectisnotentirelyattributabletospatialcorrelations.Inaddition,brain regionswhichareconnectedhavemoresimilarexpressionpatterns.Usingasimpleoptimizationapproach,weidentifieda set of genes most correlated with neuroanatomical connectivity, and find that this set is enriched for genes involved in neuronaldevelopmentandaxonguidance.Anumberofthegeneshavebeenimplicatedinneurodevelopmentaldisorders suchasautisticspectrumdisorder.Ourresultshavethepotentialtoshedlightontheroleofgeneexpressionpatternsin influencing neuronal activity and connectivity, with potential applications to our understanding of brain disorders. Supplementarydataareavailableathttp://www.chibi.ubc.ca/ABAMS. Citation: French L, Pavlidis P (2011) Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain. PLoS Comput Biol 7(1): e1001049. doi:10.1371/journal.pcbi.1001049 Editor:OlafSporns,IndianaUniversity,UnitedStatesofAmerica ReceivedJune4,2010;AcceptedDecember3,2010;PublishedJanuary6,2011 Copyright: ? 201