Relationships between Body Fat Distribution, Epicardial Fat and Obstructive Sleep Apnea in Obese Patients with and without Metabolic Syndrome 英文参考文献.docVIP

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Relationships between Body Fat Distribution, Epicardial Fat and Obstructive Sleep Apnea in Obese Patients with and without Metabolic Syndrome 英文参考文献.doc

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Relationships between Body Fat Distribution, Epicardial Fat and Obstructive Sleep Apnea in Obese Patients with and without Metabolic Syndrome 英文参考文献

RelationshipsbetweenBodyFatDistribution,Epicardial FatandObstructiveSleepApneainObesePatientswith andwithoutMetabolicSyndrome CarlaLubrano1*,MaurizioSaponara2,GiuseppeBarbaro1,PalmaSpecchia1,ElianaAddessi1, DanielaCostantini1,MartaTenuta1,GabriellaDiLorenzo1,GiuseppeGenovesi1,LorenzoM.Donini1, AndreaLenzi1,LucioGnessi1 1DepartmentofExperimentalMedicine,SectionofMedicalPhysiopathology,EndocrinologyandFoodScience,UniversityofRome‘‘Sapienza’’,Rome,Italy,2Headand NeckDepartment,UniversityofRome‘‘Sapienza’’,Rome,Italy Abstract Background: Obstructive sleep apnea (OSA) and metabolic syndrome, both closely related to obesity, often coexist in affectedindividuals;however,bodymassindexisnotanaccurateindicatorofbodyfatandthusisnotagoodpredictorof OSAandothercomorbidities.TheaimofthisstudywastoinvestigatewhethertheoccurrenceofOSAcouldbeassociated withanalteredbodyfatdistributionandamoreevidentcardiometabolicriskindependentlyfromobesityandmetabolic syndrome. Methods and Results: 171 consecutive patients (58 men and 113 women) were included in the study and underwent overnightpolysomnography.Anthropometricdata,bloodpressure,lipidprofile,glycaemicparameterswererecorded.Body composition by DXA, two-dimensional echocardiography and carotid intima/media thickness measurement were performed. 67 patients (39.2%) had no OSA and 104 (60.8%) had OSA. The percentage of patients with metabolic syndromewassignificantlyhigheramongOSApatients(65.4%)thatwereolder,heavierandshowedabiggerandfatter heartcomparedtothecontrolgroup.Upperbodyfatdepositionindex,theratiobetweenupperbodyfat(head,armsand trunk fat in kilograms) and lower body fat (legs fat in kilograms), was significantly increased in the OSA patients and significantly related to epicardial fat thickness. In patients with metabolic syndrome, multivariate regression analyses showedthatupperbodyfatdepositionindexandepicardialfatshowedthebestassociationwithOSA. Conclusion: The occurrence of OSA in obese people is more closely related to