Relative Stereochemistry of a Diterpene from Salvia cinnabarina 英文参考文献.docVIP

Molecules 2007, 12, 2279-2287 molecules ISSN 1420-3049 ? 2007 by MDPI /molecules Full Paper Relative Stereochemistry of a Diterpene from Salvia cinnabarina Angela Bisio 1, Bruno Pagano 2, Alessia Romussi 3, Olga Bruno 3, Nunziatina De Tommasi 2, Giovanni Romussi 1 and Carlo Andrea Mattia 2,* 1 Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Via Brigata Salerno, Genova, Italy 2 Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy 3 Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV, Genova, Italy * Author to whom correspondence should be addressed. E-mail: mattia@unisa.it Tel.: +39 089 969759, Fax: +39 089 969602 Received: 27 September 2007; in revised form: 5 October 2007 / Accepted: 5 October 2007 / Published: 9 October 2007 Abstract: The relative stereochemistry of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid, a diterpenoid with antispasmodic, hypotensive and antibacterial activities isolated from Salvia cinnabarina, was determined by an X-ray diffraction analysis of a single crystal of a suitable crystalline derivative. Keywords: Salvia cinnabarina, Lamiaceae, secoisopimarane-diterpene, relative stereo- chemistry, X-ray structure. Introduction The genus Salvia (family Lamiaceae) includes over 900 species growing in the temperate and tropical zones of the world; and various taxa of this genus are commonly used in traditional medicine [1]. Interesting bioactive compounds isolated from Salvia species are flavonoids, essential oils, diterpenes, and triterpenes with antifeedant, antibacterial, antifungal [2, 3], hallucinogenic [3] and antioxidant activities [4].  Molecules 2007, 12 2280 In previous papers we have described the antispasmodic, hypotensive and antibacterial activities of a new secoisopimarane diterpenoid isolated from Salvia cinnabarina M. Martens and Galeott