Renal Function and Risk of Coronary Heart Disease in General Populations New Prospective Study and Systematic Review 英文参考文献.docVIP

o PL SMEDICINE RenalFunctionandRiskofCoronary HeartDiseaseinGeneralPopulations: NewProspectiveStudyandSystematicReview Emanuele DiAngelantonio1,John Danesh1*,Gudny Eiriksdottir2,Vilmundur Gudnason2,3 1DepartmentofPublicHealthandPrimaryCare,UniversityofCambridge,Cambridge,UnitedKingdom,2IcelandicHeartAssociation,Kopavogur,Iceland,3Universityof Iceland,Reykjavik,Iceland Funding:Thisstudywassupported byaprogrammegrantfromthe BritishHeartFoundation(JDandVG) andbytheRaymondandBeverly SacklerResearchAwardinthe MedicalSciences(JD).Aspectsofthe workweresupportedbyan unrestrictededucationalgrantfrom GlaxoSmithKline(JD).Thefunding sourceshadnoroleinthestudy design,datacollectionandanalysis, decisiontopublish,orpreparation ofthemanuscript. ABSTRACT Background End-stage chronic kidney disease is associated with striking excesses of cardiovascular mortality, but it is uncertain to what extent renal function is related to risk of subsequent coronary heart disease (CHD) in apparently healthy adults. This study aims to quantify the associationofmarkersofrenalfunctionwithCHDriskinessentiallygeneralpopulations. MethodsandFindings CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. Estimated glomerular filtration rate (eGFR) was calculated using standard prediction equations based on serum creatinine measurements made in 2,007 patients diagnosed with nonfatalmyocardialinfarctionorcoronarydeathduringfollow-upandin3,869peoplewithout CHD in the Reykjavik population-based cohort of 18,569 individuals. There were small and nonsignificant odds ratios (ORs) for CHD risk over most of the range in eGFR, except in the lowestcategoryofthelowestfifth(correspondingtovaluesof,60ml/min/1.73m2),inwhich theORwas1.33(95%confidenceinterval1.01–1.75)afteradjustmentfor severalestablished cardiovascular risk factors. Findings from the Reykjavik study were reinforced by a meta- analysisofsixpreviousreports(identifiedinelectronicandotherdatabases)involvingatotalof 4,720 incide