Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates 英文参考文献.docVIP

Pharmaceuticals 2010, 3, 393-405; doi:10.3390/ph3020393 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates Karel Allegaert 1,*, Jan de Hoon 2, Anne Debeer 1 and Marc Gewillig 3 1 Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; E-Mail: anne.debeer@uz.kuleuven.ac.be (A.D.) 2 Center for Clinical Pharmacology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; E-Mail: jan.dehoon@uz.kuleuven.ac.be (J.d.H.) 3 Department of Pediatric Cardiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; E-Mail: marc.gewillig@uz.kuleuven.ac.be (M.G.) * Author to whom correspondence should be addressed; E-Mail: karel.allegaert@uz.kuleuven.ac.be; Tel.: +32-16-343211; Fax: +32-16-343209. Received: 24 November 2009; in revised form: 15 January 2010 / Accepted: 21 January 2010 / Published: 3 February 2010 Abstract: Non-steroidal anti-inflammatory drugs like ibuprofen or indomethacin are commonly prescribed drugs to induce pharmacologic closure of a patent ductus arteriosus in preterm neonates. Based on a recently published Cochrane meta-analysis, both drugs are equally effective to induce closure. Drug choice can therefore be based on differences in side effects or pharmaco-economic arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiable impact on renal function. However, compared to ibuprofen, the negative impact of indomethacin is more pronounced. Keywords: non-steroidal anti-inflammatory drugs; renal side effects; quantification 1. Introduction Renal function includes diuresis, glomerular filtration (GFR) and renal tubular activity (resorption/se