Reporting Methods of Blinding in Randomized Trials Assessing Nonpharmacological Treatments 英文参考文献.docVIP
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Reporting Methods of Blinding in Randomized Trials Assessing Nonpharmacological Treatments 英文参考文献
o
PL SMEDICINE
ReportingMethodsofBlinding
inRandomizedTrialsAssessing
NonpharmacologicalTreatments
Isabelle Boutron1,2,3*,Lydia Guittet1,2,3,Candice Estellat1,2,3,David Moher4,5,Asbj?rnHro′bjartsson6,
Philippe Ravaud1,2,3
1 INSERM, U738, Paris, France, 2 Universite′ Paris 7, UFR de Me′decine, Paris, France, 3 AP-HP, Ho?pital Bichat, De′partement d’Epide′miologie, Biostastique et Recherche
Clinique,Paris,France,4Children’sHospitalofEasternOntarioResearchInstitute,UniversityofOttawa,Ottawa,Canada,5DepartmentofEpidemiologyandCommunity
Medicine,FacultyofMedicine,UniversityofOttawa,Ottawa,Canada,6NordicCochraneCentre,Rigshospitalet,Copenhagen,Denmark
Funding:DMisfunded,inpart,bya
UniversityofOttawaResearchChair.
Thefundershadnoroleinstudy
design,datacollectionandanalysis,
decisiontopublish,orpreparation
ofthemanuscript.
ABSTRACT
Background
Blindingisacornerstoneoftreatmentevaluation.Blindingismoredifficulttoobtainintrials
assessing nonpharmacological treatment and frequently relies on ‘‘creative’’ (nonstandard)
methods.Thepurposeofthisstudywastosystematicallydescribethestrategiesusedtoobtain
blindinginasampleofrandomizedcontrolledtrialsofnonpharmacologicaltreatment.
CompetingInterests:Theauthors
havedeclaredthatnocompeting
interestsexist.
AcademicEditor:IanFord,
UniversityofGlasgow,United
Kingdom
MethodsandFindings
Citation:BoutronI,GuittetL,Estellat
C,MoherD,Hro′bjartssonA,etal.
(2007)Reportingmethodsof
We systematically searched in Medline and the Cochrane Methodology Register for
randomized controlled trials (RCTs) assessing nonpharmacological treatment with blinding,
publishedduring2004inhigh-impact-factorjournals.Datawereextractedusingastandardized
extractionform.Weidentified145articles,withthemethodofblindingdescribedin123ofthe
reports. Methods of blinding of participants and/or health care providers and/or other
caregiversconcernedmainlyuseofshamproceduressuchassimulationofsurgicalprocedures,
similarattention-controlinterventions,oraplacebowithadifferentmodeo
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