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Review of Zero-D and 1-D Models of Blood Flow in the Cardiovascular System 英文参考文献
Shietal.BioMedicalEngineeringOnLine2011,10:33
/content/10/1/33
REVIEW
OpenAccess
ReviewofZero-Dand1-DModelsofBloodFlow
intheCardiovascularSystem
YubingShi,PatriciaLawfordandRodneyHose*
*Correspondence:d.r.hose@shef.
ac.uk
Abstract
MedicalPhysicsGroup,
DepartmentofCardiovascular
Science,FacultyofMedicine,
Background:Zero-dimensional(lumpedparameter)andonedimensionalmodels,
basedonsimplifiedrepresentationsofthecomponentsofthecardiovascularsystem,
DentistryandHealth,Universityof
Sheffield,SheffieldS102RX,UK
cancontributestronglytoourunderstandingofcirculatoryphysiology.Zero-D
modelsprovideaconcisewaytoevaluatethehaemodynamicinteractionsamong
thecardiovascularorgans,whilstone-D(distributedparameter)modelsaddthe
facilitytorepresentefficientlytheeffectsofpulsewavetransmissioninthearterial
networkatgreatlyreducedcomputationalexpensecomparedtohigherdimensional
computationalfluiddynamicsstudies.Thereisextensiveliteratureonbothtypesof
models.
MethodandResults:Thepurposeofthisreviewarticleistosummarisepublished
0Dand1Dmodelsofthecardiovascularsystem,toexploretheirlimitationsand
rangeofapplication,andtoprovideanindicationofthephysiologicalphenomena
thatcanbeincludedintheserepresentations.Thereviewon0Dmodelscollects
togetherinoneplaceadescriptionoftherangeofmodelsthathavebeenusedto
describethevariouscharacteristicsofcardiovascularresponse,togetherwiththe
factorsthatinfluenceit.Suchmodelsgenerallyfeaturethemajorcomponentsofthe
system,suchastheheart,theheartvalvesandthevasculature.Themodelsare
categorisedintermsofthefeaturesofthesystemthattheyareabletorepresent,
theircomplexityandrangeofapplication:representationsofeffectsincluding
pressure-dependentvesselproperties,interactionbetweentheheartchambers,
neuro-regulationandauto-regulationareexplored.Theexaminationon1Dmodels
coversvariousmethodsfortheassembly,discretisationandsolutionofthe
governingequations,inconjunctionwithareportofthedefinitionandtreatmentof
boundaryconditions.Increasingly,0Dand1Dmodelsareusedinmulti-scalemodels,
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