Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease a case control study 英文参考文献.docVIP

Available online /content/7/5/R984 Research article Open Access Vol 7 No 5 Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study Kenneth J Warrington1, Peter D Kent1, Robert L Frye2, James F Lymp4, Stephen L Kopecky2,3, J?rg J Goronzy1,5 and Cornelia M Weyand1,5 1Division of Rheumatology, Mayo Clinic, Rochester, MN, USA 2Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA 3Mayo Alliance for Clinical Trials and the Mayo Clinic, Rochester, MN, USA 4Division of Biostatistics, Mayo Clinic, Rochester, MN, USA 5Emory University School of Medicine, Atlanta, GA, USA Corresponding author: Kenneth J Warrington, kwarring@ Received: 29 Dec 2004 Revisions requested: 27 Jan 2005 Revisions received: 23 May 2005 Accepted: 25 May 2005 Published: 29 Jun 2005 Arthritis Research Therapy 2005, 7:R984-R991 (DOI 10.1186/ar1775) This article is online at: /content/7/5/R984 ? 2005 Warrington et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The risk for cardiovascular (CV) disease is increased in rheumatoid arthritis (RA) but data on the burden of coronary atherosclerosis in patients with RA are lacking. We conducted a retrospective case-control study of Olmsted County (MN, USA) residents with RA and new-onset coronary artery disease (CAD) (n = 75) in comparison with age-and sex-matched controls with newly diagnosed CAD (n = 128). Angiographic scores of the first coronary angiogram and data on CV risk factors and CV events on follow-up were obtained by chart abstraction. Patients with RA were more likely to have multi- vessel coronary involvement at first coronary angiogram compared with controls