Rise and Demise of Bioinformatics Promise and Progress 英文参考文献.docVIP

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Rise and Demise of Bioinformatics Promise and Progress 英文参考文献.doc

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Rise and Demise of Bioinformatics Promise and Progress 英文参考文献

Review RiseandDemiseofBioinformatics?PromiseandProgress ChristosA.Ouzounis1,2 * 1Institute of Agrobiotechnology, Centre for Research Technology Hellas (CERTH), Thessaloniki, Greece, 2Donnelly Centre for Cellular Biomolecular Research, UniversityofToronto,Toronto,Ontario,Canada irrelevance,inx=651weeks,orjustoveradozenyearsfromnow. Suchatrendcriesoutforanexplanation.Whyisitthatafieldthat Abstract: Thefieldofbioinformaticsandcomputational biology has gone through a number of transformations during the past 15 years, establishing itself as a key component of new biology. This spectacular growth has appeared unstoppable in all its glory just a few years ago might alreadybeexhibitingsignsof(media)fatigue?Anddoesthistrend indicatelackofprogress,lackofinterest,both,ornoneoftheabove? been challenged by a number of disruptive changes in Wetakethisgraphasasteppingstone,anopportunitytodiscussthe science and technology. Despite the apparent fatigue of abovequestions,bearinginmindthatthisisatrendsanalysisand the linguistic use of the term itself, bioinformatics has notastrictlyscientificdiscourseonthesubject. grownperhapstoapointbeyondrecognition.Weexplore both historical aspects and future trends and argue that OneExplanation:TooMuchPromise? as the field expands, key questions remain unanswered and acquire new meaning while at the same time the range of applications is widening to cover an ever increasing number of biological disciplines. These trends appear to be pointing to a redefinition of certain objectives,milestones,andpossiblythefielditself. One way to assess the development of bioinformatics and its promised progress is by examining predictions made when the fieldfirstenteredthelimelight.Whileonemightthinkthefieldwas overly hyped, in fact most past statements have been reasonably balanced,measured,andonlysubtlyevangelicalfortheestablish- ment of computational research within the life sciences, a monumental task probably accomplished successfully. The selecte