Creatine Fails to Augment the Benefits from Resistance Training in Patients with HIV Infection A Randomized, Double-Blind, Placebo-Controlled Study 英文参考文献.docVIP

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Creatine Fails to Augment the Benefits from Resistance Training in Patients with HIV Infection A Randomized, Double-Blind, Placebo-Controlled Study 英文参考文献.doc

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Creatine Fails to Augment the Benefits from Resistance Training in Patients with HIV Infection A Randomized, Double-Blind, Placebo-Controlled Study 英文参考文献

CreatineFailstoAugmenttheBenefitsfromResistance TraininginPatientswithHIVInfection:ARandomized, Double-Blind,Placebo-ControlledStudy GiorgosK.Sakkas1,2,3,KathleenMulligan1,2,MakaniDaSilva2,JulieW.Doyle4,HootanKhatami2, ThomasSchleich5,JaneA.Kent-Braun6,MorrisSchambelan1,2* 1DepartmentofMedicine,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,2DivisionofEndocrinology,SanFranciscoGeneral Hospital, San Francisco, California, United States of America, 3Department of Medicine, University of Thessaly, Thessaly, Greece, 4Northern California Institute for ResearchandEducation,SanFrancisco,California,UnitedStatesofAmerica,5DepartmentofChemistryBiochemistry,UniversityofCaliforniaSantaCruz,SantaCruz, California,UnitedStatesofAmerica,6DepartmentofExerciseScience,UniversityofMassachusetts,Amherst,Massachusetts,UnitedStatesofAmerica Abstract Background: Progressive resistance exercise training (PRT) improves physical functioning in patients with HIV infection. Creatine supplementation can augment the benefits derived from training in athletes and improve muscle function in patientswithmusclewasting.Theobjectiveofthisstudywastodeterminewhethercreatinesupplementationaugments theeffectsofPRTonmusclestrength,energetics,andbodycompositioninHIV-infectedpatients. Methodology/Principal Findings: This is a randomized, double blind, placebo-controlled, clinical research center-based, outpatientstudyinSanFrancisco.40HIV–positivemen(20creatine,20placebo)enrolledina14-weekstudy.Subjectswere randomlyassignedtoreceivecreatinemonohydrateorplacebofor14weeks.Treatmentbeganwithaloadingdoseof20g/ day or an equivalent number of placebo capsules for 5 days, followed by maintenance dosing of 4.8g/day or placebo. Beginningatweek2andcontinuingtoweek14,allsubjectsunderwentthrice-weeklysupervisedresistanceexercisewhile continuing on the assigned study medication (with repeated 6-week cycles of loading and maintenance). The main outcome measurements included muscle strength