Defining Global Neuroendocrine Gene Expression Patterns Associated with Reproductive Seasonality in Fish 英文参考文献.docVIP

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Defining Global Neuroendocrine Gene Expression Patterns Associated with Reproductive Seasonality in Fish 英文参考文献.doc

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DefiningGlobalNeuroendocrineGeneExpression PatternsAssociatedwithReproductiveSeasonalityin Fish DapengZhang1.,HuilingXiong1.,JanA.Mennigen1,JasonT.Popesku1,VickiL.Marlatt1,ChristopherJ. Martyniuk1,KateCrump1,AndrewR.Cossins2,XuhuaXia1,VanceL.Trudeau1* 1Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, Ontario, Canada, 2School of Biological Sciences,UniversityofLiverpool,Liverpool,UnitedKingdom Abstract Background: Many vertebrates, including the goldfish, exhibit seasonal reproductive rhythms, which are a result of interactionsbetweenexternalenvironmentalstimuliandinternalendocrinesystemsinthehypothalamo-pituitary-gonadal axis. While it is long believed that differential expression of neuroendocrine genes contributes to establishing seasonal reproductiverhythms,nosystems-levelinvestigationhasyetbeenconducted. Methodology/PrincipalFindings:Inthepresentstudy,byanalyzingmultiplefemalegoldfishbrainmicroarraydatasets,we have characterized global gene expression patterns for a seasonal cycle. A core set of genes (873 genes) in the hypothalamus were identified to be differentially expressed between May, August and December, which correspond to physiologicallydistinctstagesthataresexuallymature(prespawning),sexualregression,andearlygonadalredevelopment, respectively.Expressionchangesofthesegenesarealsosharedbyanotherbrainregion,thetelencephalon,asrevealedby multivariateanalysis.Moreimportantly,byexaminingonedatasetobtainedfromfishinOctoberwhowerekeptunderlong- daylength photoperiod (16h) typical of the springtime breeding season (May), we observed that the expression of identified genes appears regulated by photoperiod, a major factor controlling vertebrate reproductive cyclicity. Gene ontologyanalysisrevealedthathormonegenesandgenesfunctionallyinvolvedinG-protein coupledreceptorsignaling pathwayandtransmissionofnerveimpulsesaresignificantlyenrichedinanexpressionpattern,whosetransitionislocated betwe