MiR-433 and miR-127 Arise from Independent Overlapping Primary Transcripts Encoded by the miR-433-127 Locus 英文参考文献.docVIP

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MiR-433 and miR-127 Arise from Independent Overlapping Primary Transcripts Encoded by the miR-433-127 Locus 英文参考文献.doc

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MiR-433 and miR-127 Arise from Independent Overlapping Primary Transcripts Encoded by the miR-433-127 Locus 英文参考文献

MiR-433andmiR-127ArisefromIndependent OverlappingPrimaryTranscriptsEncodedbythemiR- 433-127Locus GuishengSong,LiWang* DepartmentsofMedicineandOncologicalSciences,HuntsmanCancerInstitute,UniversityofUtah,SaltLakeCity,Utah,UnitedStatesofAmerica Abstract MicroRNAsplaysignificantrolesindevelopment,metabolismandcarcinogenesis,however,limitedinformationisavailable abouttheirprimarytranscriptsandthetranscriptionalregulationofthemicroRNAgenes.Wereportherethecloningoftwo primary miRNAs (pri-miR-433 and pri-miR-127) encoded by the miR-433-127 locus. Using both database mining and experimental methods, we isolated the full-length primary transcripts of the mouse miR-433 and miR-127 and demonstrated that they overlapped in a 59-39 unidirectional way. These two miRNA genes are expressed in a compact spacebyusingoverlappingcodingregions.ThisisthefirstreporttoidentifyaneconomicalstructureformiR-433andmiR- 127 genes, which may be a novel way of miRNA gene to maximize the genetic information in order to fit the complex physiologicalfunctionofmammalianorganism. Citation: Song G, Wang L (2008) MiR-433 and miR-127 Arise from Independent Overlapping Primary Transcripts Encoded by the miR-433-127 Locus. PLoS ONE3(10):e3574.doi:10.1371/journal.pone.0003574 Editor:Jean-NicolasVolff,EcoleNormaleSupe′rieure deLyon,France ReceivedAugust7,2008;AcceptedOctober9,2008;PublishedOctober30,2008 Copyright: ? 2008 Song et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:SupportedbyfundsfromAmericanLiverFoundation/AmericanAssociationfortheStudyofLiverDiseases(LiverScholarAward),AmericanDiabetes Association(JuniorFacultyAward),NIHNIDDKDK080440toL.W..Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,or preparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginteres