Role of resistin as a marker of inflammation in systemic lupus erythematosus 英文参考文献.docVIP

Available online /content/10/1/R15 Research article Open Access Vol 10 No 1 Role of resistin as a marker of inflammation in systemic lupus erythematosus Katarina Almehed, Helena Forsblad dElia, Maria Bokarewa and Hans Carlsten Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at G?teborg University Guldhedsgatan 10, S-413 46 G?teborg, Sweden Corresponding author: Katarina Almehed, katarina.almehed@vgregion.se Received: 26 Sep 2007 Revisions requested: 22 Nov 2007 Revisions received: 23 Dec 2007 Accepted: 30 Jan 2008 Published: 30 Jan 2008 Arthritis Research Therapy 2008, 10:R15 (doi:10.1186/ar2366) This article is online at: /content/10/1/R15 ? 2008 Almehed et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Resistin is a cystein-rich secretory adipokine. It is proposed to have proinflammatory properties in humans. The aim of this study was to determine associations between serum levels of resistin and markers of inflammation and bone mineral Results Serum resistin levels in controls were similar to those of patients with SLE. Markers of inflammation and current dose of glucocorticosteroids correlated positively to resistin in serum. Markers of renal function, number of prevalent vertebral fractures, and BMD were also significantly associated with resistin. In a multiple regression model, ESR, creatinine, C3, current glucocorticosteroid dose, high-density lipoprotein, and BMD radius remained significantly associated with resistin. In logistic regression analyses with resistin as the independent variable, a significant association was found with ESR (normal or elevated) but not with S-creatinine or z score for hip and radius total. Conclusi