Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning 英文参考文献.docVIP
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RoleofReuniensNucleusProjectionstotheMedial
PrefrontalCortexandtotheHippocampalPyramidalCA1
AreainAssociativeLearning
LyndellEleore,JuanCarlosLo′pez-Ramos,RafaelGuerra-Narbona,Jose′ M.Delgado-Garc?′a*
Divisio′ndeNeurociencias,UniversidadPablodeOlavide,Sevilla,Spain
Abstract
Westudiedtheinteractionsbetweenshort-andlong-termplasticchangestakingplaceduringtheacquisitionofaclassical
eyeblinkconditioningandfollowinghigh-frequencystimulation(HFS)ofthereuniensnucleusinbehavingmice.Synaptic
changesinstrengthwerestudiedatthereuniens-medialprefrontalcortex(mPFC)andthereuniens-CA1synapses.Input/
output curves and a paired-pulse study enabled determining the functional capabilities of the two synapses and the
optimalintensitiestobeappliedatthereuniensnucleusduringclassicaleyeblinkconditioningandforHFSappliedtothe
reuniensnucleus.Animalswereconditionedusingatraceparadigm,withatoneasconditionedstimulus(CS)andanelectric
shock to the trigeminal nerve as unconditioned stimulus (US). A single pulse was presented to the reuniens nucleus to
evokefieldEPSPs(fEPSPs)inmPFCandCA1areasduringtheCS-USinterval.Nosignificantchangesinsynapticstrength
wereobserved atthereuniens-mPFC andreuniens-CA1 synapses during theacquisitionof eyelid conditionedresponses
(CRs). Two successive HFS sessions carried out during the first two conditioning days decreased the percentage of CRs,
withoutevokinganylong-termpotentiation(LTP)attherecordingsites.HFSofthereuniensnucleusalsopreventedthe
properacquisitionofanobjectdiscriminationtask.AsubsequentstudyrevealedthatHFSofthereuniensnucleusevokeda
significantdecreaseofpaired-pulsefacilitation.Inconclusion,reuniensnucleusprojectionstoprefrontalandhippocampal
circuits seem to participate in the acquisition of associative learning through a mechanism that does not required the
developmentofLTP.
Citation:EleoreL,Lo′pez-RamosJC,Guerra-NarbonaR,Delgado-Garc?′aJM(2011)RoleofReuniensNucleusProjectionstotheMedialPrefrontalCortexandtothe
HippocampalPyramidalCA1AreainA
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