Science review Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance 英文参考文献.docVIP

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Science review Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance 英文参考文献.doc

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Science review Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance 英文参考文献

Available online /content/7/4/291 Review Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance Andrew JE Seely1, José L Pascual2 and Nicolas V Christou3 1Resident, Divisions of Thoracic Surgery and Critical Care Medicine, University of Ottawa, Ottawa, Ontario, Canada 2Resident, Division of General Surgery, McGill University Health Center, Montreal, Quebec, Canada 3Professor and Chief, Division of General Surgery, McGill University Health Center, Montreal, Quebec, Canada Correspondence: Andrew JE Seely, andrew.seely@sympatico.ca Published online: 9 January 2003 Critical Care 2003, 7:291-307 (DOI 10.1186/cc1853) This article is online at /content/7/4/291 ? 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract As the principal cellular component of the inflammatory host defense and contributor to host injury after severe physiologic insult, the neutrophil is inherently coupled to patient outcome in both health and disease. Extensive research has focused on the mechanisms that regulate neutrophil delivery, function, and clearance from the inflammatory microenvironment. The neutrophil cell membrane mediates the interaction of the neutrophil with the extracellular environment; it expresses a complex array of cytokines, immunoglobulins, and membrane molecules on other cells. This article presents a review and analysis of the evidence that the neutrophil membrane plays a central role in regulating neutrophil delivery (production, rolling, adhesion, diapedesis, and chemotaxis), function (priming and activation, microbicidal activity, and neutrophil-mediated host injury), and clearance (apoptosis and necrosis). In addition, we review how change in neutrophil membrane expression is synonymous with change in neutrophil function in vivo. Employing a complementary analysis of the neutrophil as a complex system, neutrophil membrane express