Screening Acute HIV Infections among Chinese Men Who Have Sex with Men from Voluntary Counseling Testing Centers 英文参考文献.docVIP

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Screening Acute HIV Infections among Chinese Men Who Have Sex with Men from Voluntary Counseling Testing Centers 英文参考文献.doc

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ScreeningAcuteHIVInfectionsamongChineseMenWhoHaveSexwithMenfromVoluntaryCounseling

ScreeningAcuteHIVInfectionsamongChineseMenWho HaveSexwithMenfromVoluntaryCounselingTesting Centers XiaoxuHan1,JunjieXu1,ZhenxingChu1,DiDai1,ChunmingLu2,XuWang3,LiZhao4,ChengZhang1, YangtaoJi1,HuiZhang1,HongShang1* 1KeyLaboratoryofAIDSImmunologyofMinistryofHealth,DepartmentofLaboratoryMedicine,No.1HospitalofChinaMedicalUniversity,Shenyang,Liaoning,China, 2HIV and Sexually Transmitted Disease Prevention and Control Institute, Liaoning Center for Disease Control and Prevention, Shenyang, Liaoning, China, 3HIV and Sexually Transmitted Disease Prevention and Control Department, Fushun Center for Disease Control and Prevention, Fushun, Liaoning, China, 4HIV and Sexually TransmittedDiseasePreventionandControlDepartment,AnshanCenterforDiseaseControlandPrevention,Anshan,Liaoning,China Abstract Background:RecentstudieshaveshownthepublichealthimportanceofidentifyingacuteHIVinfection(AHI)inthemen whohavesexwithmen(MSM)ofChina,whichhasamuchhigherriskofHIVtransmission.However,cost-utilityanalysesto guidepolicyaroundAHIscreeningarelacking. Methodology/Principal Findings: An open prospective cohort was recruited among MSM living in Liaoning Province, Northeast China. Bloodsamples andepidemiological information werecollected every10 weeks. Third-generation ELISA andrapidtestwereusedforHIVantibodyscreening,westernblotassay(WB)servedforassayvalidation.Antibodynegative specimens were tested with 24 mini-pool nucleic acid amplification testing (NAAT). Specimens with positive ELISA but negativeorindeterminateWBresultsweretestedwithNAATindividuallywithoutmixing.Acost-utilityanalysisofNAAT screeningwasassessed.Amongthe5,344follow-upvisitsof1,765MSMin22months,HIVantibodytestsdetected114HIV chronic infections, 24 seroconverters and 21 antibody indeterminate cases. 29 acute HIV infections were detected with NAATfrom21antibodyindeterminateand1,606antibodynegativecases.TheHIV-1prevalenceandincidencedensitywere 6.6% (95% CI: 5.5–7.9) and 7.1 (95% CI: 5.4–9.2)/100 person-years, respectively. With