Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression 英文参考文献.docVIP

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Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression 英文参考文献.doc

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Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression 英文参考文献

Molecules 2012, 17, 6277-6289; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression Steven Kuan-Hua Huan 1,2, Kun-Teng Wang 3,4, Shauh-Der Yeh 2, Chia-Jung Lee 3, Li-Chun Lin 3, Der-Zen Liu 5 and Ching-Chiung Wang 3,* 1 Division of Urology, Department of Surgery, Chi Mei Medical Center, No.21, Taikang, Liuying Dist., Tainan City 73657, Taiwan; E-Mail: skhsteven@.tw 2 Graduate Institute of Clinical Medical Research, Taipei Medical University, 250 Wu-Hsing Street, Taipei City 11031, Taiwan; E-Mail: d8602003@.tw 3 School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei City 11031, Taiwan; E-Mails: b8706014@.tw (K.-T.W.); m303092003@.tw (C.-J.L.); snoopy0615@ (L.-C.L.) 4 Section of Biologics Advanced Therapeutic Product Analysis, Division of Research and Analysis, Food and Drug Administration, No.161-2, Kunyang St, Nangang District, Taipei City 11561, Taiwan 5 Graduate Institute of Biomedical Materials, Taipei Medical University, 250 Wu-Hsing Street, Taipei City 11031, Taiwan; E-Mail: tonyliu@.tw * Author to whom correspondence should be addressed; E-Mail: crystal@.tw; Tel.: +886-2-2736-1661 (ext. 6161); Fax: +886-2-2732-9368. Received: 12 April 2012; in revised form: 13 May 2012 / Accepted: 15 May 2012 / Published: 25 May 2012 Abstract: Cantharidin, an active component in mylabris, is used in traditional Chinese medicine (TCM) to treat scabies and hepatoma, but accompanied by hemorrhagic cystitis. Evidence shows that cantharidin induces human bladder carcinoma cell death through COX-2 overexpression in vitro. In TCM, Scutellaria baicalensis is usually used to cure mylabris-induced hematuria. This work was undertaken to determine the mechanisms of cantharidin-induced rat hemorrhagic cystitis and explore the ur