Seasonal Differences of Gene Expression Profiles in Song Sparrow (Melospiza melodia) Hypothalamus in Relation to Territorial Aggression 英文参考文献.docVIP

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Seasonal Differences of Gene Expression Profiles in Song Sparrow (Melospiza melodia) Hypothalamus in Relation to Territorial Aggression 英文参考文献.doc

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SeasonalDifferencesofGeneExpressionProfilesinSong Sparrow(Melospizamelodia)HypothalamusinRelation toTerritorialAggression MotokoMukai1,2*,KirstinReplogle3,4,JennyDrnevich6,GangWang7¤a,DouglasWacker7¤b,MarkBand6, DavidF.Clayton3,4,5,JohnC.Wingfield1,7 1Department of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, California, United States of America, 2Department of Veterinary Biosciences,UniversityofIllinois,Champaign,Illinois,UnitedStatesofAmerica,3DepartmentofCellandDevelopmentalBiology,UniversityofIllinois,Champaign,Illinois, UnitedStatesofAmerica,4InstituteforGenomicBiology,UniversityofIllinois,Champaign,Illinois,UnitedStatesofAmerica,5NeuroscienceProgram,UniversityofIllinois, Champaign,Illinois,UnitedStatesofAmerica,6W.M.KeckCenterforComparativeandFunctionalGenomics,UniversityofIllinoisatUrbana-Champaign,Urbana,Illinois, UnitedStatesofAmerica,7DepartmentofBiology,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica Abstract Background: Male song sparrows (Melospiza melodia) are territorial year-round; however, neuroendocrine responses to simulatedterritorialintrusion(STI)differbetweenbreeding(spring)andnon-breedingseasons(autumn).Inspring,exposure toSTIleadstoincreasesinluteinizinghormoneandtestosterone,butnotinautumn.Theseobservationssuggestthatthere are fundamental differences in the mechanisms driving neuroendocrine responses to STI between seasons. Microarrays, spotted with EST cDNA clones of zebra finch, were used to explore gene expression profiles in the hypothalamus after territorialaggressionintwodifferentseasons. Methodology/Principal Findings: Free-living territorial male song sparrows were exposed to either conspecific or heterospecific (control) males in an STI in spring and autumn. Behavioral data were recorded, whole hypothalami were collected,andmicroarrayhybridizationswereperformed.QuantitativePCRwasperformedforvalidation.Ourresultsshow 262 cDNAs were differentially expressed between spring and autumn