Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype 英文参考文献.docVIP

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Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype 英文参考文献.doc

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Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype 英文参考文献

o PL SMEDICINE SeasonalChildhoodAnaemiainWestAfricaIs AssociatedwiththeHaptoglobin2-2Genotype Sarah H.Atkinson1,2,3*,Kirk Rockett3,Giorgio Sirugo1,Philip A.Bejon3,Anthony Fulford2,Maria A.O’Connell4, Robin Bailey1,Dominic P.Kwiatkowski3,Andrew M.Prentice1,2 1MedicalResearchCouncilLaboratories,Banjul,TheGambia,2MedicalResearchCouncilInternationalNutritionGroup,NutritionandPublicHealthInterventionResearch Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom,4MedicalResearchCouncil,HumanNutritionResearch,Cambridge,UnitedKingdom Funding:Wewouldliketothankthe MedicalResearchCouncilfor fundingthisstudy. ABSTRACT Background CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. Anaemia is a major cause of morbidity and mortality for children in Africa. The plasma proteinhaptoglobin(Hp)bindsavidlytofreehaemoglobinreleasedfollowingmalaria-induced haemolysis.Haptoglobinpolymorphismsresultinproteinswithalteredhaemoglobin-binding capacity and different antioxidant, iron-recycling, and immune functions. Previous studies examinedtheimportanceofhaptoglobinpolymorphisminmalariaandironhomeostasis,butit isunknownwhetherhaptoglobingenotypemightbeariskfactorforanaemiainchildrenina malaria-endemicarea. AcademicEditor:Stephen Rogerson,RoyalMelbourneHospital, Australia Citation:AtkinsonSH,RockettK, SirugoG,BejonPA,FulfordA,etal. (2006)Seasonalchildhoodanaemia inWestAfricaisassociatedwiththe haptoglobin2-2genotype.PLoS Med3(5):e172. MethodsandFindings Acohortof780ruralGambianchildrenaged2–6ywassurveyedatthestartandendofthe malaria season. Samples were taken to assess haemoglobin (Hb) concentration, iron status (ferritin, zinc protoporphyrin, transferrin saturation, and soluble transferrin receptor concen- tration), haptoglobin concentration, a-1-antichymotrypsin (a measure of inflammation), and malariaparasitesonbloodfilm.WeextractedDNAandgenotypedforha