Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT 英文参考文献.docVIP

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Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT 英文参考文献.doc

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Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT 英文参考文献

SegmentationandVisualAnalysisofWhole-BodyMouse SkeletonmicroSPECT ArtemKhmelinskii1,HaraldC.Groen2,MartinBaiker1,MariondeJong2,3,BoudewijnP.F.Lelieveldt1,4 * 1DivisionofImageProcessing,DepartmentofRadiology,LeidenUniversityMedicalCenter,Leiden,TheNetherlands,2DepartmentofNuclearMedicine,ErasmusMC, Rotterdam,TheNetherlands,3DepartmentofRadiology,ErasmusMC,Rotterdam,TheNetherlands,4DepartmentofIntelligentSystems,DelftUniversityofTechnology, Delft,TheNetherlands Abstract Whole-bodySPECTsmallanimalimagingisusedtostudycancer,andplaysanimportantroleinthedevelopmentofnew drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneityofthedata(highvolume/throughput,multi-modality,posturalandpositioningvariability).Thegoalofthis study was to provide a method to align and compare side-by-side multiple whole-body skeleton SPECT datasets in a common reference, thus eliminating acquisition variability that exists between the subjects in cross-sectional and multi- modal studies. Six whole-body SPECT/CT datasets of BALB/c mice injected with bone targeting tracers 99mTc-methylene diphosphonate(99mTc-MDP)and 99mTc-hydroxymethanediphosphonate(99mTc-HDP)wereusedtoevaluatetheproposed method.AnarticulatedversionoftheMOBYwhole-bodymouseatlaswasusedasacommonreference.Itsindividualbones wereregisteredone-by-onetotheskeletonextractedfromtheacquiredSPECTdatafollowingananatomicalhierarchical tree.Sequentialregistrationwasusedwhileconstrainingthelocaldegreesoffreedom(DoFs)ofeachboneinaccordanceto thetypeofjointanditsrangeofmotion.TheArticulatedPlanarReformation(APR)algorithmwasappliedtothesegmented dataforside-by-sidechangevisualizationandcomparisonofdata.Toquantitativelyevaluatetheproposedalgorithm,bone segmentationsofextractedskeletonsfromthecorrespondentCTdatasetswereused.Euclideanpointtosurfacedistances betweeneachdatasetandtheMOBYatlaswerecalculated.Theobtainedresultsindicatethatafterregistration,themean Euclideandistanced