Sense-antisense pairs in mammals functional and evolutionary considerations 英文参考文献.docVIP

Open Access Re rch 2007GalanteetVoal.umsea8, Issue 3, Article R40 Sense-antisense pairs in mammals: functional and evolutionary considerations Pedro AF Galante*?, Daniel O Vidal*, Jorge E de Souza*, Anamaria A Camargo* and Sandro J de Souza* Addresses: *Ludwig Institute for Cancer Research, S?o Paulo Branch, Hospital Alem?o Oswaldo Cruz, Rua Jo?o Juliao 245, 1 andar, S?o Paulo, SP 01323-903, Brazil. ?Department Of Biochemistry, University of S?o Paulo, Av. Prof. Lineu Prestes, 748 - sala 351, S?o Paulo, SP 05508-900, Brazil. Correspondence: Sandro J de Souza. Email: sandro@.br Published: 19 March 2007 Received: 3 May 2006 Revised: 4 September 2006 Accepted: 19 March 2007 Genome Biology 2007, 8:R40 (doi:10.1186/gb-2007-8-3-r40) The electronic version of this article is the complete one and can be found online at /2007/8/3/R40 ? 2007 Galante et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. aSense-antisensenpdAshnoawlyesdistohfaatpairsscoamtaeloinagrmammalseofaS-ASrtifacpairsts of cinDNtheA lhumanibrary candonstmouseructiongenomes./p revealed several putative roles for natural antisense transcripts Abstract Background: A significant number of genes in mammalian genomes are being found to have natural antisense transcripts (NATs). These sense-antisense (S-AS) pairs are believed to be involved in several cellular phenomena. Results: Here, we generated a catalog of S-AS pairs occurring in the human and mouse genomes by analyzing different sources of expressed sequences available in the public domain plus 122 massively parallel signature sequencing (MPSS) libraries from a variety of human and mouse tissues. Using this dataset of almost 20,000 S-AS pairs in both genomes we investigat