Sentinel Surveillance of Influenza-Like-Illness in Two Cities of the Tropical Country of Ecuador 2006–2010 英文参考文献.docVIP
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Sentinel Surveillance of Influenza-Like-Illness in Two Cities of the Tropical Country of Ecuador 2006–2010 英文参考文献
SentinelSurveillanceofInfluenza-Like-IllnessinTwo
CitiesoftheTropicalCountryofEcuador:2006–2010
RichardW.Douce1*,WashingtonAleman2,WilsonChicaiza-Ayala1,CesarMadrid3,MerlySovero4,
FranklinDelgado3,MireyaRodas2,JuliaAmpuero4,GloriaChauca4,JuanPerez4,JosefinaGarcia4,
TadeuszKochel4,EricS.Halsey4,V.AlbertoLaguna-Torres4
1HospitalVozandes,Quito,Ecuador,2HospitalsAlcivaryVernaza,Guayaquil,Ecuador,3HospitalNaval,Guayaquil,Ecuador,4UnitedStatesNavalMedicalResearchUnit
Six,Lima,Peru
Abstract
Background:Tropicalcountriesarethoughttoplayanimportantroleintheglobalbehaviorofrespiratoryinfectionssuch
asinfluenza.ThetropicalcountryofEcuadorhasalmostnodocumentationofthecausesofacuterespiratoryinfections.The
objectivesofthisstudyweretoidentifytheviralagentsassociatedwithinfluenzalikeillness(ILI)inEcuador,describewhat
strains of influenza were circulating in the region along with their epidemiologic characteristics, and perform molecular
characterizationofthosestrains.
Methodology/Findings:ThisisaprospectivesurveillancestudyofthecausesofILIbasedonviralcultureoforopharyngeal
specimensandcasereportformsobtainedinhospitalsfromtwocitiesofEcuadorover4years.Outof1,702casesofILI,nine
viralagentsweredetectedin597patients.Duringthetimeofthestudy,sevengeneticvariantsofinfluenzacirculatedin
Ecuador, causing six periods of increased activity. There appeared to be more heterogeneity in the cause of ILI in the
tropicalcityofGuayaquilwhencomparedwiththeAndeancityofQuito.
Conclusions/Significance:ThiswasthemostextensivedocumentationoftheviralcausesofILIinEcuadortodate.Influenza
was a common cause of ILI in Ecuador, causing more than one outbreak per year. There was no well defined influenza
seasonalthoughtherewereperiodsoftimewhennoinfluenzawasdetectedalternatingwithepidemicsofdifferentvariant
strains.
Citation:DouceRW,AlemanW,Chicaiza-AyalaW,MadridC,SoveroM,etal.(2011)SentinelSurveillanceofInfluenza-Like-IllnessinTwoCitiesoftheTropical
CountryofEcuador:2006–2010.PLoSONE6(8):e22206.doi:10.1371/jo
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