Sentinel Surveillance of Influenza-Like Illness in Two Hospitals in Maracay, Venezuela 2006–2010 英文参考文献.docVIP
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Sentinel Surveillance of Influenza-Like Illness in Two Hospitals in Maracay, Venezuela 2006–2010 英文参考文献
SentinelSurveillanceofInfluenza-LikeIllnessinTwo
HospitalsinMaracay,Venezuela:2006–2010
GuillermoComach1*,NimfaTeneza-Mora2,TadeuszJ.Kochel2,3,CarlosEspino1,GloriaSierra1,
DariaE.Camacho1,V.AlbertoLaguna-Torres3,JosefinaGarcia3,GloriaChauca3,MariaE.Gamero3,
MerlySovero3,SlaveBordones4,IrisVillalobos5,AngelMelchor6,EricS.Halsey3
1LaboratorioRegionaldeDiagnosticoeInvestigaciondelDengueyotrasEnfermedadesVirales(LARDIDEV),InstitutodeInvestigacionesBiomedicasdelaUniversidadde
Carabobo(BIOMED-UC),Maracay,Venezuela,2NavalMedicalResearchCenter,SilverSpring,Maryland,UnitedStatesofAmerica,3U.S.NavalMedicalResearchUnitSix
(NAMRU-6), Lima, Peru, 4Hospital Jose′ Mar?′a Caraban?o Tosta, Instituto Venezolano de los Seguros Sociales, Maracay, Venezuela, 5Hospital Central de Maracay,
Corporacio′ndeSaluddeAragua(CORPOSALUDARAGUA),Maracay,Venezuela,6Direccio′ndeEpidemiolog?′a,Corporacio′ndeSaluddeAragua(CORPOSALUDARAGUA),
Maracay,Venezuela
Abstract
Background:LimitedinformationexistsontheepidemiologyofacutefebrilerespiratoryillnessesintropicalSouthAmerican
countriessuchasVenezuela.Theobjectiveofthepresentstudywastoexaminetheepidemiologyofinfluenza-likeillness
(ILI)intwohospitalsinMaracay,Venezuela.
Methodology/Principal Findings: We performed a prospective surveillance study of persons with ILI who presented for
care at two hospitals in Maracay, Venezuela, from October 2006 to December 2010. A respiratory specimen and clinical
informationwereobtainedfromeachparticipant.Viralisolationandidentificationwithimmunofluorescentantibodiesand
molecularmethodswereemployedtodetectrespiratoryvirusessuchasadenovirus,influenzaAandB,parainfluenza,and
respiratorysincytialvirus,amongothers.Therewere916participantsinthestudy(medianage:17years;range:1month–
86years).Viruseswereidentifiedin143(15.6%)subjects,andoneparticipantwasfoundtohaveaco-infectionwithmore
thanonevirus.Influenzaviruses,includingpandemicH1N12009,werethemostfrequentlydetectedpathogens,accounting
for67.4%(97/144)ofthevirusesdetected.A
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