Sentinel Surveillance of Influenza-Like Illness in Two Hospitals in Maracay, Venezuela 2006–2010 英文参考文献.docVIP

Sentinel Surveillance of Influenza-Like Illness in Two Hospitals in Maracay, Venezuela 2006–2010 英文参考文献.doc

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Sentinel Surveillance of Influenza-Like Illness in Two Hospitals in Maracay, Venezuela 2006–2010 英文参考文献

SentinelSurveillanceofInfluenza-LikeIllnessinTwo HospitalsinMaracay,Venezuela:2006–2010 GuillermoComach1*,NimfaTeneza-Mora2,TadeuszJ.Kochel2,3,CarlosEspino1,GloriaSierra1, DariaE.Camacho1,V.AlbertoLaguna-Torres3,JosefinaGarcia3,GloriaChauca3,MariaE.Gamero3, MerlySovero3,SlaveBordones4,IrisVillalobos5,AngelMelchor6,EricS.Halsey3 1LaboratorioRegionaldeDiagnosticoeInvestigaciondelDengueyotrasEnfermedadesVirales(LARDIDEV),InstitutodeInvestigacionesBiomedicasdelaUniversidadde Carabobo(BIOMED-UC),Maracay,Venezuela,2NavalMedicalResearchCenter,SilverSpring,Maryland,UnitedStatesofAmerica,3U.S.NavalMedicalResearchUnitSix (NAMRU-6), Lima, Peru, 4Hospital Jose′ Mar?′a Caraban?o Tosta, Instituto Venezolano de los Seguros Sociales, Maracay, Venezuela, 5Hospital Central de Maracay, Corporacio′ndeSaluddeAragua(CORPOSALUDARAGUA),Maracay,Venezuela,6Direccio′ndeEpidemiolog?′a,Corporacio′ndeSaluddeAragua(CORPOSALUDARAGUA), Maracay,Venezuela Abstract Background:LimitedinformationexistsontheepidemiologyofacutefebrilerespiratoryillnessesintropicalSouthAmerican countriessuchasVenezuela.Theobjectiveofthepresentstudywastoexaminetheepidemiologyofinfluenza-likeillness (ILI)intwohospitalsinMaracay,Venezuela. Methodology/Principal Findings: We performed a prospective surveillance study of persons with ILI who presented for care at two hospitals in Maracay, Venezuela, from October 2006 to December 2010. A respiratory specimen and clinical informationwereobtainedfromeachparticipant.Viralisolationandidentificationwithimmunofluorescentantibodiesand molecularmethodswereemployedtodetectrespiratoryvirusessuchasadenovirus,influenzaAandB,parainfluenza,and respiratorysincytialvirus,amongothers.Therewere916participantsinthestudy(medianage:17years;range:1month– 86years).Viruseswereidentifiedin143(15.6%)subjects,andoneparticipantwasfoundtohaveaco-infectionwithmore thanonevirus.Influenzaviruses,includingpandemicH1N12009,werethemostfrequentlydetectedpathogens,accounting for67.4%(97/144)ofthevirusesdetected.A

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