Seropositivity of Lyme Borreliosis and Associated Risk Factors A Population-Based Study in Children and Adolescents in Germany (KiGGS) 英文参考文献.docVIP

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Seropositivity of Lyme Borreliosis and Associated Risk Factors A Population-Based Study in Children and Adolescents in Germany (KiGGS) 英文参考文献.doc

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Seropositivity of Lyme Borreliosis and Associated Risk Factors A Population-Based Study in Children and Adolescents in Germany (KiGGS) 英文参考文献

SeropositivityofLymeBorreliosisandAssociatedRisk Factors:APopulation-BasedStudyinChildrenand AdolescentsinGermany(KiGGS) ManuelDehnert1,VolkerFingerle2,ChristianeKlier2,ThomasTalaska3,MartinSchlaud4,Ge′rardKrause1, HendrikWilking1*,GabrielePoggensee1 1Department for Infectious Disease Epidemiology, Robert Koch-Institute, Berlin, Germany, 2National Reference Centre for Borrelia, Bavarian Food and Health Safety Authority,Oberschlei?heim,Germany,3InstituteforTickborneDiseases,Brieskow-Finkenheerd,Germany,4DepartmentofEpidemiologyandHealthReporting,Robert Koch-Institute,Berlin,Germany Abstract Background:Lymeborreliosis(LB)causedbyspirochetesoftheBorreliaburgdorferisensulatocomplexisthemostcommon tick-bornediseaseinthenorthernhemisphere.DataonthedistributionandonriskfactorsinGermanyaresketchy. Methodology/PrincipalFindings:Bloodsamplesofanationwidepopulation-basedcross-sectionalstudyfrom2003–2006 inchildrenandadolescentsaged1to17yearsinGermany(KiGGS)wereanalysed(n=12,614)toassesstheseroprevalence of anti-Borrelia antibodies. Data from standardized interviews were used to assess potential risk factors. First, sera were screened for anti-Borrelia antibodies by ELISA. The overall prevalence was 4.8% (95% confidence interval (CI) 4.3–5.4%). PositiveandborderlineELISAtestresultswereconfirmedbyalineblotrevealingacombinedprevalenceof4.0%(95%CI 3.6–4.5%). Seroprevalence of ELISA was significantly higher in males (odds ratio (OR)=1.37; CI 1.15–1.63) and in the southern part of Germany (OR=1.41; CI 1.09–1.83), but significantly lower in children and adolescents with migration background(OR=0.33;CI0.24–0.44).Studyparticipantsfromhouseholdswithcatshadahigherchanceofseropositivity (OR=6.7;CI5.6–8.0).Inamultivariablemodeltheoddsofseropositivityincreasesby11%foreveryyearofageforboysand 6%forgirls. Conclusions/Significance: This survey is the first nationwide, representative seroprevalence survey of LB in children and youngadolescents.ThestudyshowsthatinfectionswithBorreliaburgdorfer