Shunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development 英文参考文献.docVIP

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Shunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development 英文参考文献.doc

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Shunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development 英文参考文献

ShuntingInhibitionControlstheGainModulation MediatedbyAsynchronousNeurotransmitterReleasein EarlyDevelopment VladislavVolman1,2,3*,HerbertLevine1,TerrenceJ.Sejnowski1,2,3,4 1CenterforTheoreticalBiologicalPhysics,UniversityofCaliforniaatSanDiego,LaJolla,California,UnitedStatesofAmerica,2ComputationalNeurobiologyLaboratory, TheSalkInstituteforBiologicalStudies,LaJolla,California,UnitedStatesofAmerica,3HowardHughesMedicalInstitute,TheSalkInstituteforBiologicalStudies,LaJolla, California,UnitedStatesofAmerica,4DivisionofBiologicalSciences,UniversityofCaliforniaatSanDiego,LaJolla,California,UnitedStatesofAmerica Abstract Thesensitivityofaneurontoitsinputcanbemodulatedinseveralways.Changesintheslopeoftheneuronalinput-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent synaptic excitation, and balanced excitation and inhibition. However, in early development GABAergic interneurons are excitatory and other mechanisms such as asynchronous transmitter release might contribute to regulating neuronal sensitivity. We modeled bothphasicandasynchronoussynaptictransmissioninearlydevelopmenttostudytheimpactofactivity-dependentnoise andshort-termplasticity on thesynaptic gain.Asynchronous release decreasedorincreased thegaindependingon the membraneconductance.Inthehighshuntregime,excitatoryinputduetoasynchronousreleasewasdivisive,whereasin thelowshuntregimeithadanearlymultiplicativeeffectonthefiringrate.Inaddition,sensitivitytocorrelatedinputswas influenced by shunting and asynchronous release in opposite ways. Thus, asynchronous release can regulate the informationflowatsynapsesanditsimpactcanbeflexiblymodulatedbythemembraneconductance. Citation:VolmanV,LevineH,SejnowskiTJ(2010)ShuntingInhibitionControlstheGainModulationMediatedbyAsynchronousNeurotransmitterReleaseinEarly Development.PLoSComputBiol6(11):e1000973.doi:10.1371/journal.pcbi.1000973 Editor:LyleJ.Graham,Universite′ ParisDescartes,CentreNationaldelaRechercheScientifique,F