Signal Regulatory Protein α (SIRPα)+ Cells in the Adaptive Response to ESAT-6CFP-10 Protein of Tuberculous Mycobacteria 英文参考文献.docVIP

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Signal Regulatory Protein α (SIRPα)+ Cells in the Adaptive Response to ESAT-6CFP-10 Protein of Tuberculous Mycobacteria 英文参考文献.doc

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SignalRegulatoryProteinα(SIRPα)CellsintheAdaptiveResponsetoESAT-6CFP-10ProteinofTuberculousMycobacteria英文参考文献

SignalRegulatoryProteina(SIRPa)+CellsintheAdaptive ResponsetoESAT-6/CFP-10ProteinofTuberculous Mycobacteria W.RayWaters1*,MitchellV.Palmer1,BrianJ.Nonnecke1,TylerC.Thacker1,D.MarkEstes2,MichelleH. Larsen3,WilliamR.JacobsJr3,PeterAndersen4,JamesMcNair5, F.C.Minion6,KonstantinP. Lyashchenko7,R.GlynHewinson8,H.MartinVordermeier8,RandyE.Sacco1 1National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America, 2University of Texas Medical Branch,Department ofPediatrics andtheSealyCenterforVaccineDevelopment,Galveston,Texas,UnitedStatesofAmerica, 3HowardHughesMedicalInstituteand DepartmentofMicrobiologyandImmunology,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,4StatensSerumInstitute,Copenhagen, Denmark,5BacteriologyDepartment,VeterinarySciencesDivision,Stormont,Belfast,6VeterinaryMicrobiologyandPreventiveMedicine,IowaStateUniversity,Ames, Iowa,UnitedStatesofAmerica,7ChembioDiagnosticSystems,Medford,NewYork,UnitedStatesofAmerica,8UKVeterinaryLaboratoriesAgency,Weybridge,NewHaw, Addlestone,Surrey,UnitedKingdom Abstract Background:Earlysecretoryantigenictarget-6(ESAT-6)andculturefiltrateprotein-10(CFP-10)areco-secretedproteinsof Mycobacteriumtuberculosiscomplexmycobacteria(includesM.bovis,thezoonoticagentofbovinetuberculosis)involvedin phagolysosomeescapeofthebacillusand,potentially,intheefficientinductionofgranulomas.Upontuberculosisinfection, multi-nucleategiantcellsareelicited,likelyasaresponseaimedatcontainingmycobacteria.Intissueculturemodels,signal regulatoryprotein(SIRP)a(alsoreferredtoasmacrophagefusionreceptororCD172a)isessentialformulti-nucleategiant cellformation. Methodology/PrincipalFindings:Inthepresentstudy,ESAT-6/CFP-10complexandSIRPainteractionswereevaluatedwith samplesobtainedfromcalvesexperimentallyinfectedwithM.bovis.PeripheralbloodCD172a+(SIRPa-expressing)cellsfrom M.bovis-infectedcalvesproliferateduponinvitrostimulationwithESAT-6/CFP-10(eitherasafusio