Single Nucleotide Polymorphisms in the PRDX3 and RPS19 and Risk of HPV Persistence and Cervical PrecancerCancer 英文参考文献.docVIP

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Single Nucleotide Polymorphisms in the PRDX3 and RPS19 and Risk of HPV Persistence and Cervical PrecancerCancer 英文参考文献.doc

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Single Nucleotide Polymorphisms in the PRDX3 and RPS19 and Risk of HPV Persistence and Cervical PrecancerCancer 英文参考文献

SingleNucleotidePolymorphismsinthePRDX3and RPS19andRiskofHPVPersistenceandCervical Precancer/Cancer MahboobehSafaeian1*,AllanHildesheim1,PaulaGonzalez2,KaiYu1,CarolinaPorras2,QizhaiLi3 ,Ana CeciliaRodriguez2,MarkE.Sherman1,MarkSchiffman1,SholomWacholder1,RobertBurk4, RolandoHerrero2,LaurieBurdette5,StephenJ.Chanock5,SophiaS.Wang6 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America, 2Proyecto Epidemiolo′gico Guanacaste, Fundacio′nINCIENSA,SanJose′, CostaRica,3AcademyofMathematicsandSystemsScience,ChineseAcademyofSciences,Beijing,China,4AlbertEinsteinCollegeof Medicine,Bronx,NewYork,UnitedStatesofAmerica,5CoreGenotypingFacility,DivisionofCancerEpidemiologyandGenetics,AdvancedTechnologyProgram,SAIC FrederickInc,NCI-Frederick,Frederick,Maryland,UnitedStatesofAmerica, 6DivisionofEtiology,DepartmentofPopulationSciences,CityofHope,Duarte,California, UnitedStatesofAmerica Abstract Background: Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus(HPV),theetiologicagentforcervicalcancer,topersistentHPVinfection,andhencetocervicalprecancer andcancer. Methodology/PrincipalFindings:Weassessed18,310tagsinglenucleotidepolymorphisms(SNPs)from1113genesin416 cervical intraepithelial neoplasia 3 (CIN3)/cancer cases, 356 women with persistent carcinogenic HPV infection (median persistenceof25months)and425randomlyselectedwomen(non-casesandnon-HPVpersistent)fromthe10,049women fromtheGuanacaste, CostaRica HPVnaturalhistorycohort. ForgeneandSNPassociations, wecomputedage-adjusted odds ratioandp-trend. Three comparisons were made:1) association withCIN3/cancer (compared CIN3/cancer cases to random controls), 2) association with persistence (compared HPV persistence to random controls), and 3) progression (comparedCIN3/cancerswithHPV-persistentgroup).RegionsstatisticallysignificantlyassociatedwithCIN3/cancerincluded genes for peroxiredoxin 3 PRDX3, and rib