Smoking and prevalence of allergic disorders in Japanese pregnant women baseline data from the Kyushu Okinawa Maternal and Child Health Study 英文参考文献.docVIP
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Tanakaetal.EnvironmentalHealth2012,11:15
/content/11/1/15
RESEARCH
OpenAccess
Smokingandprevalenceofallergicdisordersin
Japanesepregnantwomen:baselinedatafrom
theKyushuOkinawaMaternalandChildHealth
Study
KeikoTanaka1*,YoshihiroMiyake1andMasashiArakawa2
Abstract
Background:Studiesontheassociationsbetweensmokingandallergicdiseaseshavemostlyfocusedonasthma.
Epidemiologicalstudiesinadultsontheeffectsofsmokingonallergicdiseasesotherthanasthma,suchaseczema
andrhinoconjunctivitis,havebeenlimited,andtheinformationthatisavailablehasbeeninconsistent.Theaimof
thisstudywastoinvestigatetheassociationbetweensmokingstatusandenvironmentaltobaccosmoke(ETS)
exposureandtheprevalenceofallergicdiseases.
Methods:Studysubjectswere1743pregnantJapanesewomen.Thedefinitionsofwheezeandasthmawere
basedoncriteriafromtheEuropeanCommunityRespiratoryHealthSurveywhereasthoseofeczemaand
rhinoconjunctivitiswerebasedoncriteriafromtheInternationalStudyofAsthmaandAllergiesinChildhood.
Adjustmentwasmadeforage;regionofresidence;familyhistoryofasthma,atopiceczema,andallergicrhinitis;
householdincome;andeducation.
Results:Comparedwithneversmoking,currentsmokingand≥4pack-yearsofsmokingwereindependently
positivelyassociatedwiththeprevalenceofwheeze.Therewerenoassociationsbetweensmokingstatusandthe
prevalenceofasthma,eczema,orrhinoconjunctivitis.Whensubjectswhohadneversmokedwereclassifiedinto
fourcategoriesbasedonthesourceofETSexposure(never,onlyathome,onlyatwork,andboth),exposure
occurringbothathomeandatworkwasindependentlyassociatedwithanincreasedprevalenceoftwo
outcomes:wheezeandrhinoconjunctivitis.NorelationshipswereobservedbetweenexposuretoETSandthe
prevalenceofasthmaoreczema.
Conclusions:OurresultsprovideevidencethatcurrentsmokingandETSexposuremayincreasethelikelihoodof
wheeze.ThepossibilityofapositiveassociationbetweenETSexposureandrhinoconjunctivitiswasalsosuggested.
Keywords:Asthma,Cross-sectionalstudies,Eczema,Environmentaltobaccosmoke,Smoking,Wheeze,
Rhinoconjunctivitis
Introduction
and most eviden
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