Splicing bioinformatics to biology 英文参考文献.docVIP

Meeting report Splicing bioinformatics to biology Douglas L Black* and Brenton R Graveley? Addresses: *Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095-1662, USA. ?Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3301, USA. Correspondence: Douglas L Black. Email: dougb@ Published: 26 May 2006 Genome Biology 2006, 7:317 (doi:10.1186/gb-2006-7-5-317) The electronic version of this article is the complete one and can be found online at /2006/7/5/317 ? 2006 BioMed Central Ltd identified conserved features that predict base pairing A report on the 2nd Symposium on Alternative Transcript between a docking site in the intron upstream of the array Diversity, Heidelberg, Germany, 21-23 March 2006. and selector sequences adjacent to each alternative exon. This finding leads to a unique model for the regulation of exon 6 splicing, in which mutually exclusive pairing between Alternative splicing affects many aspects of eukaryotic biology and is studied by groups with diverse interests. Geneticists and biochemists have long been interested in understanding the molecular mechanisms that underlie changes in splice-site choice, and the role of splicing regula- tion in particular biological systems. More recently, compu- tational biologists have entered the field with the goals of defining the products of genomes and understanding the role of alternative splicing in genome evolution. Although their interests broadly overlap, these fields often utilize dis- tinct languages, and there have been relatively few meetings dedicated to bringing the two groups together. Exceptions have been the symposia on alternative transcript diversity organized by the European Molecular Biology Laboratory-