Structural genomics and structural biology compare and contrast 英文参考文献.docVIP

Meeting report Structural genomics and structural biology: compare and contrast John-Marc Chandonia*, Thomas N Earnest? and Steven E Brenner*? Addresses: *Berkeley Structural Genomics Center and ?Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. ?Department of Plant and Microbial Biology, 461A Koshland Hall, University of California, Berkeley, CA 94720-3102, USA. Correspondence: Steven E Brenner. E-mail: brenner@ Published: 25 August 2004 Genome Biology 2004, 5:343 The electronic version of this article is the complete one and can be found online at /2004/5/9/343 ? 2004 BioMed Central Ltd produce 75 structures in 2004; similar scaling up is A report on the Keystone Symposium ‘Structural Genomics’, reported by most other centers. The NESGC has success- held concurrently with the ‘Frontiers in Structural Biology’ fully developed software to recognize innaccurate structures symposium, Snowbird, USA, 13-19 April 2004. automatically, and to speed up the solution of structures by nuclear magnetic resonance (NMR) spectroscopy through automatic assignment of peaks on the NMR spectrum to atoms in the structure. The NESGC has also set up an auto- Is structural genomics a visionary undertaking heralding the future of structural biology, or merely a billion-dollar-plus mated pipeline to annotate proteins of known structure but unknown function. folly? Two concurrent Keystone Symposia, ‘Structural Genomics’ and ‘Frontiers in Structural Biology’, brought together leading structural biologists and pioneers of the structural genomics community, providing an exciting oppor- tunity to contrast cutting-edge advances in the two fields. The advances in structural genomics have focused on providing value for money: improved automation has resulted in expanded productivity. We expect the resulting flood of struc- tures to provide an