Superparamagnetic Nanocomposites Templated with Pyrazole-Containing Diblock Copolymers 英文参考文献.docVIP

Polymers 2012, 4, 1211-1225; doi:10.3390/polym4021211 OPEN ACCESS Polymers ISSN 2073-4360 /journal/polymers Article Superparamagnetic Nanocomposites Templated with Pyrazole-Containing Diblock Copolymers Sanchita Biswas 1, Kevin D. Belfield 1,*, Ritesh K. Das 2, Siddhartha Ghosh 2 and Arthur F. Hebard 2 1 Department of Chemistry, University of Central Florida, P.O. Box 162366, Orlando, FL 32816, USA; E-Mail: sbiswas@ 2 Department of Physics, University of Florida, Gainesville, FL 32611, USA; E-Mails: rkdas@ (R.K.D.); ghoshsi@ (S.G.); afh@ (A.F.H.) * Author to whom correspondence should be addressed; E-Mail: belfield@; Tel.: +1-407-823-1028; Fax: +1-407-823-2252. Received: 19 March 2012; in revised form: 26 April 2012 / Accepted: 14 May 2012 / Published: 31 May 2012 Abstract: Monodisperse maghemite nanoparticles, templated in novel, well-defined pyrazole-containing norbornene-based block copolymers, provided a superparamagnetic nanocomposite with high saturation magnetization at room temperature under an applied magnetic field. The synthesis of the polymer nanocomposites and physical, morphological, and magnetic chracaterization of the nanocomposites are reported. Micelle-encapsulated superparamagnetic nanocomposites were generated for dispersal in aqueous medium. Their stability in water in the presence of a magnetic field was investigated as was their morphology and cell viability, strongly suggesting the potential of these superparamagnetic polymer-based nanocomposites in certain biomedical imaging and associated applications. Keywords: block copolymer; polymeric nanocomposite; maghemite; ROMP; chelating ligand 1. Introduction There has been great interest in magnetic nanoparticles for a number of biomedical applications, including medical diagnosis and imaging, magnetic separation, magnetic hyperthermia, and controlled drug delivery [1–7] as well as for biomimetic applications [8–10], such as magn