The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis 英文参考文献.docVIP

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The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis 英文参考文献.doc

The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis 英文参考文献

Pérez-Casaletal.CriticalCare2011,15:R195 /content/15/4/R195 RESEARCH OpenAccess Theclinicalandfunctionalrelevanceof microparticlesinducedbyactivatedproteinC treatmentinsepsis MargaritaPérez-Casal1,VictoriaThompson3,ColinDowney1,IngeborgWelters3,DuncanWyncoll4,JeckoThachil1,3 andChengHockToh1,2,3* Abstract Introduction:ActivatedproteinC(APC)inducesreleaseofmicroparticles(MP)fromprimaryphysiologicalcells, whicharefoundinpatientsundergoingtreatmentwithrecombinanthumanAPC(rhAPC)forseveresepsis.We hypothesisedthatAPConthesecirculatingMPsactivateendothelialprotease-activatedreceptor1(PAR1)toinduce

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The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis 英文参考文献.docVIP