The Feasibility of Enzyme Targeted Activation for Amino AcidDipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzyme 英文参考文献.docVIP

Molecules 2012, 17, 3672-3689; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Feasibility of Enzyme Targeted Activation for Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzyme Yasuhiro Tsume 1 and Gordon L. Amidon 2,* 1 Department of Pharmaceutical Science, University of Michigan, Ann Arbor, MI 48109, USA; E-Mail: ytsume@ 2 College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA * Author to whom correspondence should be addressed; E-Mail: glamidon@; Tel.: +