Thyroid function in Danish greenhouse workers 英文参考文献.docVIP

Environmental Health: A Global Access Science Source BioMedCentral Research Open Access Thyroid function in Danish greenhouse workers Gunnar Toft*1, Allan Flyvbjerg2 and Jens Peter Bonde1 Address: 1Department of Occupational Medicine, Aarhus University Hospital, Norrebrogade 44, build 2C, DK-8000 Aarhus C, Denmark and 2The Medical Research Laboratories, Clinical Institute and Medical Department M (Diabetes and Endocrinology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark Email: Gunnar Toft* - gutof@as.aaa.dk; Allan Flyvbjerg - allan.flyvbjerg@dadlnet.dk; Jens Peter Bonde - jpbon@as.aaa.dk * Corresponding author Published: 06 December 2006 Received: 21 August 2006 Accepted: 06 December 2006 Environmental Health: A Global Access Science Source 2006, 5:32 doi:10.1186/1476-069X-5- 32 This article is available from: /content/5/1/32 ? 2006 Toft et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: From animal studies it is known that currently used pesticides can disturb thyroid function. Methods: In the present study we investigated the thyroid function in 122 Danish greenhouse workers, to evaluate if greenhouse workers classified as highly exposed to pesticides experiences altered thyroid levels compared to greenhouse workers with lower exposure. Serum samples from the greenhouse workers were sampled both in the spring and the fall to evaluate if differences in pesticide use between seasons resulted in altered thyroid hormone levels. Results: We found a moderate reduction of free thyroxine (FT4) (10–16%) among the persons working in greenhouses with a high spraying load both in samples collected in the spring and the fall, but none of the other measured thyroid hormon