Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients 英文参考文献.docVIP

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Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients 英文参考文献.doc

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Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients 英文参考文献

Available online /content/12/4/R106 Research Open Access Vol 12 No 4 Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients HaiHong Wang1*, BaoLi Cheng1*, QiXing Chen1,2, ShuiJing Wu1, Chen Lv1, GuoHao Xie1, Yue Jin1 and XiangMing Fang1 1Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, QingChun Road, Hangzhou 310003, PR China 2Key Laboratory of Multiple Organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, School of Medicine, Zhejiang University, QingChun Road, Hangzhou 310003, PR China * Contributed equally Corresponding author: XiangMing Fang, xiangming_fang@163.com Received: 12 Apr 2008 Revisions requested: 30 May 2008 Revisions received: 7 Aug 2008 Accepted: 17 Aug 2008 Published: 17 Aug 2008 Critical Care 2008, 12:R106 (doi:10.1186/cc6988) This article is online at: /content/12/4/R106 ? 2008 Wang et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Gelsolin is an actin-binding plasma protein that is part of an actin-scavenging system. Studies suggest that plasma gelsolin may play a crucial role in the pathophysiology of sepsis. Little is known about the course of plasma gelsolin levels over time in patients with severe sepsis. The aim of the study was to investigate plasma gelsolin levels in severe septic patients and to determine whether these levels predict the severity or clinical outcome of severe sepsis. Results The admission gelsolin levels were significantly decreased in severe sepsis (20.6 ± 11.7 mg/l) compared with nonseptic critically ill patients (52.3 ± 20.3 mg/l; P 0.001) and healthy control individuals (126.8 ±