Tracing the evolution of tissue identity with microRNAs 英文参考文献.docVIP

De Mulder and Berezikov Genome Biology 2010,11:111 /2010/11/3/111 RESEARCH HIGHLIGHT Tracing the evolution of tissue identity with microRNAs Katrien De Mulder and Eugene Berezikov* to their translational inhibition and/or degradation. Abstract Given that miRNAs control gene expression in a wide range of biological processes, including developmental timing, cell proliferation and di?erentiation, it is feasible that alterations in spatio-temporal expression of miRNAs during evolution could result in signi?cant changes in physiology and morphology between di?erent taxa. Comparison of microRNA expression identied tissues present in the last common ancestor of Bilaterians and put evolution of microRNAs in the context of tissue evolution. Novel miRNAs continuously evolve in animal genomes Animal evolution has fascinated biologists for centuries [7]. Once integrated into a gene regulatory network, and, despite tremendous progress in our understanding miRNAs are strongly conserved and not susceptible to of the evolutionary process, it still keeps many of its signi?cant secondary loss. As such, miRNA studies mysteries secret. Initially, morphological and develop- partially overcome the limitations faced by morpho- mental studies were performed to reconstruct the road logical, developmental and protein comparison that animal evolution has followed. With the coming of approaches, such as parallel evolution, convergence and age of molecular biology, comparative single- and multiple- missing data. ese appealing characters rapidly attracted gene analyses contributed to the further unraveling of the attention of evolutionary biologists, and miRNAs evolutionary relationships within the animal kingdom. became a promising tool for reconstructing animal Although these studies resulted in the se