Transcriptional regulatory network for sexual differentiation in fission yeast 英文参考文献.docVIP

Open Access Re rch 2007MataetVoal.lumesea8, Issue 10, Article R217 Transcriptional regulatory network for sexual differentiation in fission yeast Juan Mata*?, Anna Wilbrey*? and Jürg B?hler* Addresses: *Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1HH, UK. ?Current address: Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, UK. ?Current address: The Babraham Institute, B501, Babraham Research Campus, Cambridge CB22 3AT, UK. Correspondence: Juan Mata. Email: jm593@cam.ac.uk Published: 10 October 2007 Received: 17 July 2007 Revised: 11 September 2007 Accepted: 10 October 2007 Genome Biology 2007, 8:R217 (doi:10.1186/gb-2007-8-10-r217) The electronic version of this article is the complete one and can be found online at /2007/8/10/R217 ? 2007 Mata et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SexualtiaptioMnicrdifferentiationreovaerarlasyinasnigahlytssinisinofissiontfotthheetrryeasteanscriptomegulatory prinofcifissionples conyeasttrolliafterng thgenetice gene eperturbationxpression proofgr6amgenesdrivknowning thistoprhaveocessa.role/pin sexual differen- Abstract Background: Changes in gene expression are hallmarks of cellular differentiation. Sexual differentiation in fission yeast (Schizosaccharomyces pombe) provides a model system for gene expression programs accompanying and driving cellular specialization. The expression of hundreds of genes is modulated in successive waves during meiosis and sporulation in S. pombe, and several known transcription factors are critical for these processes. Results: We used DNA microarrays to investigate meiotic ge