Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes 英文参考文献.docVIP

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Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes 英文参考文献.doc

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Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes 英文参考文献

Open Access Re rch 2007CurtisetVoal.lumesea8, Issue 12, Article R262 Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes Christina Curtis*, Gary N Landis*, Donna Folk?, Nancy B Wehr?, Nicholas Hoe*, Morris Waskar*, Diana Abdueva*§, Dmitriy Skvortsov*, Daniel Ford*, Allan Luu*, Ananth Badrinath*, Rodney L Levine?, Timothy J Bradley?, Simon Tavaré*? and John Tower* Addresses: *Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-1340, USA. ?Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92717, USA. ?Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20817-6735, USA. §Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9034, USA. ?Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, UK. Correspondence: John Tower. Email: jtower@ Published: 9 December 2007 Received: 23 July 2007 Revised: 12 September 2007 Accepted: 9 December 2007 Genome Biology 2007, 8:R262 (doi:10.1186/gb-2007-8-12-r262) The electronic version of this article is the complete one and can be found online at /2007/8/12/R262 ? 2007 Curtis et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MnSOD-mediatedsipstinTgrapnrsicmriaprtiiloynoaflife-spanlcparrobfoilhinydgextensionroafteMmnSetOaDinbo-mlfliesisediatedm and elife-spanlectron trextensionansport geinneDrosophilas./p identifies a set of candidate biomarkers of aging, con- Abstract Background: Several interventions increase lifespan