Translational disease interpretation with molecular networks 英文参考文献.docVIP

Review Translational disease interpretation with molecular networks Ana?s Baudot*, Gonzalo Gómez-López* and Alfonso Valencia *These authors contributed equally to this work Address: Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, E-28029 Madrid, Spain. Correspondence: Alfonso Valencia. Email: avalencia@cnio.es Published: 29 June 2009 Genome Biology 2009, 10:221 (doi:10.1186/gb-2009-10-6-221) The electronic version of this article is the complete one and can be found online at /2009/10/6/221 ? 2009 BioMed Central Ltd Abstract Molecular networks are being used to reconcile genotypes and phenotypes by integrating medical information. In this context, networks will be instrumental for the interpretation of disease at the personalized medicine level. Genes and proteins do not function in isolation in the cell, but are integrated into a global network of interactions between cellular components. Even if current networks the study of their cellular functions. We will then consider the use of network analysis and bioinformatics to integrate high-throughput information on networks of interactions to better understand the functional cellular defects underlying complex multifactorial diseases. Finally, we consider how molecular networks could be used to link disease genotypes and phenotypes, and propose the use of networks to integrate scattered information - connecting genomic know- ledge, detailed molecular information and precise medical descriptions of diseases, and ultimately taking into account an individual’s genetic background to provide effective personalized medicine. mainly describe protein-protein interactions, other biological relations, including gene regulation, control by small RNAs, enzymatic reactions and other interactions, are progressively being integrated. The complete netw