Treatment of acute hepatitis C virus infection with interferon-α 2b and ribavirin Case report and review of the literature 英文参考文献.docVIP

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Treatment of acute hepatitis C virus infection with interferon-α 2b and ribavirin Case report and review of the literature 英文参考文献.doc

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Treatment of acute hepatitis C virus infection with interferon-α 2b and ribavirin Case report and review of the literature 英文参考文献

Annals of Clinical Microbiology and Antimicrobials BioMedCentral 1 Case Report Open Access Annals2002, of Clinical Microbiology and Antimicrobials x Treatment of acute hepatitis C virus infection with inter feron- 2b and ribavirin: Case report and review of the literature Hakan Leblebicioglu*, Derya Bayirli, Saban Esen, Mustafa Sunbul and Cafer Eroglu Address: Department of Infectious Diseases and Clinical Microbiology Ondokuz Mayis University Medical School Samsun, Turkey E-mail: Hakan Leblebicioglu* - hakanomu@.tr; Derya Bayirli - dbayirli@.tr; Saban Esen - sabanes@.tr; Mustafa Sunbul - msunbul@.tr; Cafer Eroglu - ceroglu@.tr *Corresponding author Published: 14 October 2002 Received: 31 August 2002 Accepted: 14 October 2002 Annals of Clinical Microbiology and Antimicrobials 2002, 1:3 This article is available from: /content/1/1/3 ? 2002 Leblebicioglu et al; licensee BioMed Central Ltd. This article is published in Open Access: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Hepatitis C virus (HCV) infection becomes chronic in about 85 % of individuals as demonstrated by the persistence of HCV. It is necesseray to treat acute hepatitis C infection. Interferon- is generally used for the treatment of acute HCV infection. Case presentation: A 55-year-old woman with a history of fatique and icter was diagnosed as acute hepatitis C virus infection. She was treated with interferon- 2b 3 million unite sc three times in a week and ribavirin 1000 mg daily for 6 months. Within 2 weeks of therapy, the alanine aminotransferase (ALT) had became normal. At the end of the 3 months of therapy, HCV RNA was negative and remained negative 6 months after the end of interferon treatment (sustained response). Conclusion: This report suggests that interferon- 2b and ribavirin may have a role in tr