Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity 英文参考文献.docVIP

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Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity 英文参考文献.doc

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Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity 英文参考文献

Behavioral and Brain Functions BioMedCentral Research Open Access Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity Nancy Gerits*1, Werner Van Belle2 and Ugo Moens1 Address: 1Department of Microbiology and Virology, Institute of Medical Biology, Faculty of Medicine, University of Troms?, N-9037 Troms?, Norway and 2Department of Medical Genetics, University Hospital of Northern-Norway, N-9036 Troms?, Norway Email: Nancy Gerits* - nancy@; Werner Van Belle - werner@; Ugo Moens - ugo.moens@fagmed.uit.no * Corresponding author Published: 12 November 2007 Received: 28 September 2007 Accepted: 12 November 2007 Behavioral and Brain Functions 2007, 3:58 doi:10.1186/1744-9081-3-58 This article is available from: /content/3/1/58 ? 2007 Gerits et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The mitogen-activated protein kinases, MAPKs for short, constitute cascades of signalling pathways involved in the regulation of several cellular processes that include cell proliferation, differentiation and motility. They also intervene in neurological processes like fear conditioning and memory. Since little remains known about the MAPK-Activated Protein Kinase, MAPKAPK5, we constructed the first MAPKAPK knockin mouse model, using a constitutive active variant of MAPKAPK5 and analyzed the resulting mice for changes in anxiety-related behaviour. Methods: We performed primary SHIRPA observations during background breeding into the C57BL/6 background and assessed the behaviour of the background-bred animals on the elevated plus maze and in the light-dark test. Our results were analyzed using Chi-square tests